Efficacy validation of synthesized retinol derivatives In vitro: stability, toxicity, and activity

Retinal production from β-carotene by β-carotene 15,15′-dioxygenase from an unculturable marine bacterium

“…This is the most likely cause of the observed enzyme instability. Moreover, carotenoids and retinoids decompose over time in the reaction because they are unstable compounds (Osuna-Garcia et al 1997;Han et al 2003). As a control, the concentration of bcarotene was monitored in the absence of enzyme.…”

A newly synthesized photostable retinol derivative (retinyl N-formyl aspartamate) for photodamaged skin: Profilometric evaluation of 24-week study

“…15 Retinyl N-formyl aspartamate, which has the same effects as retinoic acid but does not have the side effects associated with retinoic acid such as skin irritation, itching, and photoinstability, may solve these problems. 1 This study demonstrated a reduction in the severity of fine wrinkles using a topical application of retinyl N-formyl aspartamate in women with facial photodamage. Because the clinical effects began at week 16 of the study, retinyl N-formyl aspartamate likely needs to be applied for more than 16 weeks to achieve appreciable effects.…”

“…In addition, the cosmetic use of retinol is limited by side effects, such as skin irritation. 1 To solve these problems, many groups have synthesized various retinol derivatives, 2 blended retinol with soybean oil, 3 or microencapsulated retinol. 4 One retinol derivative, retinyl palmitate, has been used widely in cosmetics for years.…”

“…In an in vivo study, retinyl N-formyl aspartamate showed better antiaging effect than retinal, was more stable under sunlight than retinol, and was as stable as retinyl palmitate at 408C for 10 days. 1 The aim of this study was to compare the efficacy and tolerance of retinyl N-formyl aspartamate with a placebo.…”

Formulation and evaluation of Antiwrinkle activity of Cream and Nano emulsion of Moringa oleifera seed oil

“…www.iosrjournals.org 60 | Page Firstly, the animals under study are subjected to UVB irradiation at suberythemal doses for upto 2weeks at 345nm which will produce marked wrinkling 8,9,10 . Skin topography analysis was performed on the skin surface of mice before and after treatment for measuring the effectiveness of M. Olifera.…”