The paper empirically investigates the effects of governance (GGov), official development assistance (ODA), sustainability [adjusted net savings (ANS)], and macroeconomic variables on the quality of life [human development index (HDI)] for selected sub-Saharan African (SSA) countries using the most recent data from 2000 to 2017. The study employed different panel techniques. The findings provide insightful and interesting empirical results that resonate with the magnitude of a significant of the role of GGov on ANS and HDI. Our study shows that GGov is important to improve HDI. Additionally, ANS has important implications on the well-being of human existence in SSA. In addition to these, this study found that macroeconomic variables such as trade openness and economic growth, wealth, and opportunity creation factors like urbanization and electrification rate are essential. Furthermore, empirical results revealed that ODA has a negative and significant association with HDI, which is in line with some of the existing literature. Our findings have several implications for organizations such as the World Bank, International Monetary Fund, and African Development Bank. This study serves as a policy instrument and guides in coordinating SSA on promoting HDI. 1 | INTRODUCTION Globally, the sub-Saharan African (SSA) region has the highest record of under-5 child mortality and the least life expectancy at birth of 52.5 years (Akobeng, 2017). The disparity between life expectancy of the developed and developing economies in this region is wide. The African continent is the poorest. For instance, the life expectancy of a Japanese person is 86.8 years as compared to a person living in Sierra Leone averaging 49.3 years for men and 50.8 years for women (Arimah, 2004; Bloom et al., 1998; Hanmer et al., 1999). Poverty is a crucial factor that militates against quality of life. A 2018 World Bank report indicates that there was an increase in the number of poor people in Africa from 280 million in the year 1990 to 330 million in 2012 (World Bank, 2018). About 50% of the population in Africa live on less than a dollar a day (Arimah, 2004). It is borne out of several social and economic factors, such as unemployment and lack of social support systems, which predispose people to all kinds of economic hardships including the inability to afford health care and basic necessities in life. These factors come together to affect people's quality of life. Many factors can affect the quality of life status and a country's ability to respond to the needs of its population. Among these factors are good governance (GGov), official aids, and a sustainable community. This paper examines the effects of sustainable development, GGov, aid, and macroeconomic variables on the quality of life for a sample of 26 SSA countries for the period 2000-2017. The estimation was done using different panel technique models. The main results show a positive relationship between GGov and quality of life. Also, sustainable development contributes positively to quali...