Efficiency and Safety of Chinese Herbal Medicine in the Treatment of Prediabetes: A Systemic Review and Meta‐Analysis of Randomized Controlled Trials

Song, Yanan; Wang, Haiyan; Qin, Lingling; Li, Mei; Gao, Saiyue; Wu, Lili; Liu, Tonghua

doi:10.1155/2020/3628036

Cited by 4 publications

(1 citation statement)

References 52 publications

(53 reference statements)

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“…Prediabetes is a subhealth condition characterized by higher than normal blood sugar levels, but not yet at a sufficiently high level to warrant a diagnosis of type 2 diabetes mellitus (T2DM) [ 1 ]. The American Diabetes Association proposes a diagnosis of prediabetes according to a fasting plasma glucose (FPG) level in the range of 100-125 mg/dL, hemoglobin A 1c (HbA 1c ) in the range of 5.7%-6.4%, or 2-hour postprandial blood glucose level after the 75-g oral glucose test in the range of 140-199 mg/dL [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

The Effectiveness of a Traditional Chinese Medicine–Based Mobile Health App for Individuals With Prediabetes: Randomized Controlled Trial

Chung¹,

Tai²,

Chang³

et al. 2023

JMIR Mhealth Uhealth

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Background Traditional Chinese medicine (TCM) theories assert that body constitution and meridian energy lay the foundation for disease prevention. TCM-based health concepts have not yet been incorporated into mobile health (mHealth) apps for individuals with prediabetes. Objective The aim of this study was to examine the effectiveness of a TCM mHealth app for individuals with prediabetes. Methods This randomized controlled trial recruited 121 individuals with prediabetes at a teaching hospital in New Taipei City between February 2020 and May 2021. The participants were randomly assigned to the TCM mHealth app group (n=42), ordinary mHealth app group (n=41), or control group (n=38). All participants received the usual care that included 15-20 minutes of health education about the disease, along with healthy diet and exercise encouragement. The ordinary mHealth app included physical activity (PA), diet, and disease education, along with individual records. The TCM mHealth app additionally included qi and body constitution information, along with constitution-based PA and diet advice. The control group received the usual care alone and did not have access to any app. Data were collected at baseline, at the end of the 12-week intervention, and 1 month after the intervention. Body constitution, including yang-deficiency, yin-deficiency, and phlegm-stasis, was measured according to the Body Constitution Questionnaire, with higher scores indicating a greater deficiency. Body energy was examined using the Meridian Energy Analysis Device. The Short-Form 36 questionnaire was used to evaluate health-related quality of life (HRQOL), which yielded physical component scores and mental component scores, with higher scores indicating better physical and mental aspects of HRQOL, respectively. Results Compared to the control group, the TCM mHealth app group showed greater improvement in hemoglobin A1c (HbA1c), yang-deficiency and phlegm-stasis body constitution, and BMI; however, no significant differences were found in these outcomes between the TCM mHealth app and ordinary mHealth app groups. The TCM mHealth app group showed better improvement in body energy and mental component scores than the ordinary mHealth app group. There were no significant differences in fasting plasma glucose, yin-deficiency body constitution, Dietary Approaches to Stop Hypertension dietary behavior, and total PA among the three groups after the intervention. Conclusions Use of either the ordinary or TCM mHealth app improved HRQOL among individuals with prediabetes. Compared to the outcomes of controls not using any app, use of the TCM mHealth app was effective at improving HbA1c, BMI, yang-deficiency and phlegm-stasis body constitution, and HRQOL. Moreover, using the TCM mHealth app seemed to improve the body energy and HRQOL more than when using the ordinary mHealth app. Further studies with a larger sample size and longer follow-up period may be necessary to determine whether the differences favoring the TCM app are clinically meaningful. Trial Registration ClinicalTrials.gov NCT04096989; https://clinicaltrials.gov/ct2/show/NCT04096989

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Section: Introductionmentioning

confidence: 99%

The Effectiveness of a Traditional Chinese Medicine–Based Mobile Health App for Individuals With Prediabetes: Randomized Controlled Trial

Chung¹,

Tai²,

Chang³

et al. 2023

JMIR Mhealth Uhealth

View full text Add to dashboard Cite

show abstract

A randomized, controlled, comparative, proof-of-concept study to evaluate the efficacy and safety of Nisha-Amalaki capsules in prediabetic patients for preventing progression to diabetes

Munshi,

Karande-Patil,

Kumbhar

et al. 2023

Journal of Ayurveda and Integrative Medicine

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The Effectiveness of a Traditional Chinese Medicine–Based Mobile Health App for Individuals With Prediabetes: Randomized Controlled Trial (Preprint)

Chung¹

2022

Preprint

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BACKGROUND Traditional Chinese Medicine (TCM) theories assert that body constitution and meridian energy lay the foundation for disease prevention. TCM-based health concepts have not been incorporated into the mHealth app for persons with prediabetes. OBJECTIVE The study aimed to examine the effectiveness of a TCM mHealth app for individuals with prediabetes. METHODS This randomized controlled trial recruited 121 individuals with prediabetes at a teaching hospital in New Taipei City between February 2020 and May 2021. The participants were randomly assigned to TCM mHealth app (n=42), ordinary mHealth app (n=41), or control group (n=38). The ordinary mHealth app included physical activity (PA), diet, disease education, and individual records. The TCM m-Health app additionally included qi and body constitution as well as constitution-based PA and diet advices. The control group did not receive apps. Data were collected at baseline, the end of the 12-weeks intervention, and 1 month after the intervention. Body constitution was measured by the body constitution questionnaire, which yielded yang-deficiency, ying-deficiency, and phlegm-stasis, with higher scores indicating a greater deficiency. Meridian energy was examined by using the Meridian Energy Analysis Device. The Short-Form 36 was used to evaluate health-related quality of life (HRQOL), which yielded physical component scores (PCS) and mental component scores (MCS), with higher scores indicating better physical and mental aspects of HRQOL, respectively. RESULTS Compared to the control group, the TCM mHealth app group had a significant improvement after the intervention in yang-deficiency ( =-3.15, P=.04) and phlegm-stasis ( =-3.45, P=.04) body constitution, bladder ( =10.79, P =.02) and gallbladder meridian energy ( =13.10, P =.01), PCS ( =4.93, P=.001), and MCS ( =8.11, P<.001). They also improved greater in HbA1c ( =-0.11, P =.03), body mass index (BMI, =-0.37, P =.04), small intestine meridian energy ( =16.38, p=.04), phlegm-stasis body constitution ( =-3.30, P =.02), PCS ( =4.89, P=.001), and MCS ( =7.26, P<.001) at 1 month after the intervention compared to the control group. The ordinary mHealth app group had a greater increase in MCS ( =4.63, P =.02) at the end of intervention compared to the control group. CONCLUSIONS The TCM mHealth app can be used in health management for individuals with prediabetes to improve their blood sugar control, BMI, body constitution, meridian energy, and HRQOL. CLINICALTRIAL ClinicalTrials.gov NCT04096989; https://clinicaltrials.gov/ct2/show/ NCT04096989

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Efficiency and Safety of Chinese Herbal Medicine in the Treatment of Prediabetes: A Systemic Review and Meta‐Analysis of Randomized Controlled Trials

Cited by 4 publications

References 52 publications

The Effectiveness of a Traditional Chinese Medicine–Based Mobile Health App for Individuals With Prediabetes: Randomized Controlled Trial

The Effectiveness of a Traditional Chinese Medicine–Based Mobile Health App for Individuals With Prediabetes: Randomized Controlled Trial

A randomized, controlled, comparative, proof-of-concept study to evaluate the efficacy and safety of Nisha-Amalaki capsules in prediabetic patients for preventing progression to diabetes

The Effectiveness of a Traditional Chinese Medicine–Based Mobile Health App for Individuals With Prediabetes: Randomized Controlled Trial (Preprint)

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