Efficiency of a New Combined Laser Therapy in Patients With Trophic Ulcers of Lower Extremities and Chronic Venous Insufficiency

Moskvin, S V; Geynitz, Aleksandr Vladimirovich; Асхадулин, Е. В.

doi:10.15171/jlms.2017.24

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…A second Scopus database search was undertaken to evaluate the effects of green light PBM using the terms described in Figure 3b. An initial search resulted in 236 articles being identified and these articles were subsequently screened for suitability, which then identified 32 relevant articles for further review (18,32,33,64,68,69,79,164,168,171,176,177,186,197,205,209,(212)(213)(214)(215)(216)(217)(218)(219)(220)(221)(222)(223)(224)(225)(226)(227).…”

Section: Kazemi Khoo Et Al 2013(184)mentioning

confidence: 99%

Under the spotlight: mechanisms of photobiomodulation concentrating on blue and green light

Serrage

Heiskanen

Palin

et al. 2019

Photochem Photobiol Sci

104

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Section: Kazemi Khoo Et Al 2013(184)mentioning

confidence: 99%

Under the spotlight: mechanisms of photobiomodulation concentrating on blue and green light

Serrage

Heiskanen

Palin

et al. 2019

Photochem Photobiol Sci

104

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“…In recent years, the interest in the application of laser therapy in supporting chronic wound healing has increased 9 , 10 , 11 . However, the effectiveness and usefulness of this method has not been unequivocally confirmed so far.…”

Section: Introductionmentioning

confidence: 99%

Effect of laser therapy on expression of angio- and fibrogenic factors, and cytokine concentrations during the healing process of human pressure ulcers

et al. 2018

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Objective: To evaluate the effect of laser irradiation at different wavelengths on the expression of selected growth factors and inflammatory mediators at particular stages of the wound healing process.Methods: Sixty-seven patients were recruited, treated, and analyzed (group A - 940 nm: 17 patients; group B - 808 nm: 18 patients; group C - 658 nm: 16 patients; group D - sham therapy: 17 patients). Patients received a basic treatment, including repositioning and mobilization, air pressure mattress and bed support surfaces, wound cleansing and drug therapy. Additionally, patients received laser therapy once a day, 5 times a week for 1 month in use of a semiconductor lasers (GaAlAs) which emitted a continuous radiation emission at separate wavelengths of 940 nm (group A), 808 nm (group B) and 658 nm (group C). In group D (sham therapy), laser therapy was applied in the same manner, but the device was off during each session (only the applicator was switched on to scan pressure ulcers using none coherent red visible light).Results: The positive changes in the measured serum (IL-2, IL-6 and TNF-α) and wound tissue (TNF-α, VEGF and TGFβ1) parameters appeared to be connected only with the wavelength of 658 nm. The significant change in pro-inflammatory mediator levels [interleukin 2 (IL-2) with p=0.008 and interleukin 6 (IL-6) with p=0.016] was noticed after two weeks of laser therapy. In the other groups, the inflammation was also reduced, but the process was not as marked as in group C. Similarly, in the case of tumor necrosis factor (TNF-α) concentration, where after two weeks of treatment with irradiation at a wavelength of 658 nm, a rapid suppression was observed (p=0.001), whereas in the other groups, these results were much slower and not as obvious. Interestingly, again in the case of group C, the change in TNF-α concentration in wound tissue was most intensive (≈75% reduction), whereas the changes in other groups were not as obvious (≈50% reduction). After irradiation (658 nm), the VEGF expression increased significantly within the first two weeks, and then it decreased and maintained a stable level. In contrast, the TGFβ1 activity remained level, but always higher in comparison to other groupsConclusions: The effective healing of pressure ulcers is connected with laser irradiation at a wavelength of 658 nm. We believe that this effect is related to the inhibition of inflammatory processes in the wound and stimulation of angiogenesis and fibroblast proliferation at this specific radiation (based both on concentration of interleukins and TNF-α serum level and VEGF, TGFβ1, TNF-α activities in wound biopsies). Laser therapy at wavelengths of 940 and 808 nm does not significantly affect the above-mentioned repair processes, which explains its low effectiveness in the treatment of pressure ulcers.

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Laser in Wound Care

Ricci

2023

Pearls and Pitfalls in Skin Ulcer Management

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Efficiency of a New Combined Laser Therapy in Patients With Trophic Ulcers of Lower Extremities and Chronic Venous Insufficiency

Cited by 6 publications

References 5 publications

Under the spotlight: mechanisms of photobiomodulation concentrating on blue and green light

Under the spotlight: mechanisms of photobiomodulation concentrating on blue and green light

Effect of laser therapy on expression of angio- and fibrogenic factors, and cytokine concentrations during the healing process of human pressure ulcers

Laser in Wound Care

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