Efficiency of an Air Filter at the Drainage Site in a Closed Circuit with a Centrifugal Blood Pump: An In Vitro Study

Mitsumaru, Atsuhiro; Yozu, Ryohei; Matayoshi, Toru; Morita, Masanori; Shin, Hankei; Tsutsumi, Koji; Iino, Yoshimi; Kawada, Shiaki

doi:10.1097/00002480-200111000-00024

Cited by 14 publications

(9 citation statements)

References 12 publications

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“…To minimize microbubble entry to the circulation, a filter is attached to the tube that returns the blood to the patient. This solution is incomplete, as bubbles have been detected in the cerebral circulation (14,15).…”

Section: Introductionmentioning

confidence: 99%

Reviews: Pathophysiology and Clinical Implications of Microbubbles during Hemodialysis

Barák

Nakhoul

Katz

2008

Seminars in Dialysis

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Microbubbles have been detected in the human circulation of end-stage renal disease patients who are treated by hemodialysis throughout the past decade as a result of advanced ultrasound and Doppler technology. These detection tools uncovered signals of microbubbles, which originate in extracorporeal lines and tubing of hemodialysis machine, circulate in the blood stream until lodging in the capillary bed of various organs, mainly the lungs. During its course within the capillary, a bubble abrades the glycocalyx layer lining the surface of the vessels and thereafter obstructs blood flow through the capillary. This causes tissue ischemia, inflammatory response, and complement activation. Aggregation of platelets and clot formation occurs as well, leading to further obstruction of the microcirculation and subsequent tissue damage. In this review, we describe the biological and clinical effects of microbubbles during hemodialysis and discuss management with regard to prevention and treatment.

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Section: Introductionmentioning

confidence: 99%

Reviews: Pathophysiology and Clinical Implications of Microbubbles during Hemodialysis

Barák

Nakhoul

Katz

2008

Seminars in Dialysis

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“…Concerns over patient safety by using a MECC system without a safety feature to remove venous air have been raised [ 57,58 ] . Under such circumstances, a potential risk for continuous microair embolisation exists during perfusion.…”

Section: Venous Bubble Trapmentioning

confidence: 99%

MECC Equipment

Anastasiadis¹,

Antonitsis²,

Argiriadou³

2012

Principles of Miniaturized ExtraCorporeal Circulation

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“…Various in vitro studies have shown that the air handling capability of closed-loop systems is low compared to conventional CPB systems (3,14,20). In contrast, two recent studies reported a lower embolic load in patients perfused with a MECC system as compared to a conventional CPB system during CABG (10,11).…”

Section: Air Removal Efficiency Of a Venous Bubble Trap 1095mentioning

confidence: 99%

“…Others have also raised their concerns over patient safety by using a miniaturized extracorporeal circulation system, without a safety feature to remove venous air (13,14).…”

mentioning

confidence: 99%

Air Removal Efficiency of a Venous Bubble Trap in a Minimal Extracorporeal Circuit During Coronary Artery Bypass Grafting

et al. 2010

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The use of minimized extracorporeal circuits (MECC) in cardiac surgery is expanding. These circuits eliminate volume storage and bubble trap reservoirs to minimize the circuit. However, this may increase the risk of gaseous micro emboli (GME). To reduce this risk, a venous bubble trap was designed. This study was performed to evaluate if incorporation of a venous bubble trap in a MECC system as compared to our standard minimized extracorporeal circuit without venous bubble trap reduces gaseous micro emboli during cardiopulmonary bypass (CPB). Forty patients were randomly assigned to be perfused either with or without an integrated venous bubble trap. After preliminary evaluation of the data of 23 patients, the study was terminated prior to study completion. The quantity and volume of GME were significantly lower in patients perfused with a venous bubble trap compared to patients perfused without a venous bubble trap. The present study demonstrates that a MECC system with a venous bubble trap significantly reduces the volume of GME and strongly reduces the quantity of large GME (>500 µm). Therefore, the use of a venous bubble trap in a MECC system is warranted.

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Efficiency of an Air Filter at the Drainage Site in a Closed Circuit with a Centrifugal Blood Pump: An In Vitro Study

Cited by 14 publications

References 12 publications

Reviews: Pathophysiology and Clinical Implications of Microbubbles during Hemodialysis

Reviews: Pathophysiology and Clinical Implications of Microbubbles during Hemodialysis

MECC Equipment

Air Removal Efficiency of a Venous Bubble Trap in a Minimal Extracorporeal Circuit During Coronary Artery Bypass Grafting

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