Efficiency of antifungal sublingual allergen-specific immunotherapy in patients under and over 50 years old with mild persistent and moderate bronchial asthma

Петренко, Л.Л.; Rekalova, E. M.

doi:10.15587/2519-4798.2017.100270

Cited by 1 publication

(1 citation statement)

References 8 publications

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“…У хворих на БА з гіперчутливістю до грибко вих антигенів, зокрема A. fumigatus, вражаючі результати показала АСІТ. За 12 міс лікування в пацієнтів спостері гали значні покращення показників ФЗД, а також зни зилась шкірна чутливість до фунгальних антигенів [10]. Однак це дослідження проводилося на пацієнтах з БА без встановленого АБЛА.…”

Section: лікуванняunclassified

Allergic bronchopulmonary aspergillosis: XXI century. A modern view on the problem

Перцева¹,

Gashynova²,

Sokur³

2018

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Aspergillus organisms are widely ubiquitous in the environment and can cause a great number of pathological syndromes mainly in immunocom promised patients. However, aspergillosis lesion may occur not only in patients with immunodeficiency. Allergic bronchopulmonary aspergillosis is a noninvasive form of Aspergillus lung disease, occurring in nonimmunocompromised patients and manifesting with poorly controlled severe asthma. The pathogenesis of this disease is not understood completely. But there are a lot of investigations those can shed the light on some mechanisms of disease development. The diagnosis is based on results of different tests such as aspergillus skintest, total and specific serum IgE levels, specific se rum IgG levels, highresolution computed tomography, investigation of sputum culture etc. Based on typical symptoms and data of laboratory and instrumental methods, diagnostic criteria were formulated. Purposes of treatment includes asthma control, prevention and treatment of exacerbations, prevention of bronchiectasis development. The basic principles of treatment are immunosuppression and eradication of the pathogen from the or ganism. Oral and inhaled corticosteroids, antifungal drugs and antiIgE monoclonal antibodies are used. But there are not official recommendations about dosage, drug regimen and duration of treatment. Therefore, treatment options described in different works are based on individual experience of patient management. The development of molecular allergology opens new perspectives for diagnosis and treatment of this disease. New antigenic components of A. fumigatus are released and new vaccine for antigenspecific immunotherapy are developed. But efficiency and expediency of this diagnostic and treatment method need to be investigated.

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Section: лікуванняunclassified

Allergic bronchopulmonary aspergillosis: XXI century. A modern view on the problem

Перцева¹,

Gashynova²,

Sokur³

2018

View full text Add to dashboard Cite

show abstract

Efficiency of antifungal sublingual allergen-specific immunotherapy in patients under and over 50 years old with mild persistent and moderate bronchial asthma

Cited by 1 publication

References 8 publications

Allergic bronchopulmonary aspergillosis: XXI century. A modern view on the problem

Allergic bronchopulmonary aspergillosis: XXI century. A modern view on the problem

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