Efficiency of Carbonyl Iron in Prevention of Anaemia in Piglets

Svoboda, Martin; Ficek, Radek; Synková, B.; Drábek, J.

doi:10.2754/avb200776020179

Cited by 7 publications

(7 citation statements)

References 14 publications

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“…However, the intake was not sufficient at restoring iron status and the mean Hb level in-group CON was 76.2 g/L at day 21 postpartum. A value comparable to Hb levels found in other studies ( Svoboda et al, 2007 ; Ettle et al, 2008 ; Stojanac et al, 2016 ). In addition, 70 % of the CON piglets had Hb levels below 90 g/L and were thus defined as anemic and only 4.4 % was defined as normal at day 21 (Hb > 110 g/L).…”

Section: Discussionsupporting

confidence: 89%

Peroral iron supplementation can be provided to piglets through a milk cup system with results comparable to parenteral iron administration

Jakobsen

Pedersen

Amdi

2021

Translational Animal Science

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The objective of this study was to investigate if iron can be allocated to piglets through sow milk replacer fed in a milk cup system with efficacies comparable to intramuscular (IM) administration of 200 mg gleptoferron. Two hundred and ninety-four piglets from 21 litters were allocated to three different iron treatments (n = 98). The treatments were 1) Control (CON) provided no supplemental iron, 2) Injected iron (II) provided 200 mg gleptoferron IM on day 3 postpartum, and 3) Milk iron (MI) provided sow milk replacer “DanMilk Supreme” added 1 % “Piglet Boozt” ad libitum from day 0 until 21 days postpartum. All piglets had access to dry feed from day 6. Initial and final body weight was registered and hemoglobin (Hb) levels were analyzed on day 0, 3, 7, 10, 17, and 21 after farrowing. In order to correlate drinking pattern with Hb level and growth, video cameras were installed, and drinking pattern was recorded on day 18 postpartum. A blood sample was drawn from piglets from three litters per treatment on day 21 for a complete hematology profile. The results showed that iron treatment had an effect on Hb levels (P < 0.001) that were different between all groups from day 10, resulting in a mean Hb level of 76.2 g/L (CON), 120.9 g/L (II), and 105.4 g/L (MI) on day 21. The mean Hb level for both MI and II was above the anemia threshold of 90 g/L and the Hb level of the II group was above 110 g/L and the piglets thus defined as normal. Treatment had a significant effect on Hb, hematocrit (hct), mean corposcular volume (MCV), mean corpuscular hemoglobin (MCH), red blood cell distribution width (RDW), lymphocytes (%), neutrophils (bill/L) (P < 0.05), neutrophils (%) (P < 0.01), with CON being significantly different from MI and II that were similar or tended to differ. Total visits at the cup was not correlated to Hb level (r = 0.08) and growth was not affected by treatment (P = 0.99). It is concluded that iron can be supplemented to piglets through a milk cup system with efficacies comparable to parenteral administration of 200 mg gleptoferron.

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Section: Discussionsupporting

confidence: 89%

Peroral iron supplementation can be provided to piglets through a milk cup system with results comparable to parenteral iron administration

Jakobsen

Pedersen

Amdi

2021

Translational Animal Science

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“…Iron supplements as feed additives. Over the years, various dietary iron supplements such as iron salts [63], iron chelates [13], carbonyl iron [64], iron polymaltose [65], and iron microparticles [66] have been used to prevent/treat IDA in piglets. Despite such huge diversity of oral iron supplements, there is a general consensus that dietary supplementation with iron is less efficient in rectifying hematological status of piglets compared with parenteral one (reviewed in [10]).…”

Section: Iron Supplementation Of Pigletsmentioning

confidence: 99%

Iron Supplementation in Suckling Piglets: An Ostensibly Easy Therapy of Neonatal Iron Deficiency Anemia

et al. 2018

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In pigs, iron deficiency anemia (IDA) is the most prevalent deficiency disorder during the early postnatal period, frequently developing into a serious illness. On the other hand, in humans, only low-birth-weight infants, including premature infants, are especially susceptible to developing IDA. In both human and pig neonates, the initial cause of IDA is low birth iron stores. In piglets this shortage of stored iron results mainly from genetic selection over the past few decades for large litter sizes and high birth weights. As a consequence, pregnant sows cannot provide a sufficient amount of iron to the increasing number of developing fetuses. Supplementation with iron is a common practice for the treatment of IDA in piglets. For decades, the preferred procedure for delivering iron supplements during early life stages has been through the intramuscular injection of a large amount of iron dextran. However, this relatively simple therapy, which in general, efficiently corrects IDA, may generate toxic effects, and by inducing hepcidin expression, may decrease bioavailability of supplemental iron. New iron supplements are considered herein with the aim to combine the improvement of hematological status, blunting of hepcidin expression, and minimizing the toxicity of the administered iron. We propose that iron-deficient piglets constitute a convenient animal model for performing pre-clinical studies with iron supplements.

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“…For this reason, iron supplementation is a key element in piglet performance during the first week of life (Svoboda et al 2004(Svoboda et al , 2007. Several studies suggest that low neonate birth weight is negatively associated with perinatal survival (England 1974;Caceres et al 2001;Herpin et al 2002;Mota-Rojas et al 2008).…”

Section: How Do We Establish the Vitality Score And Measure Latency Tmentioning

confidence: 99%

Animal welfare in the newborn piglet: a review

Mota-Rojas¹,

Martı́nez-Burnes²,

Villanueva-García³

et al. 2012

Vet. Med.

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ABSTRACT:The objective of this review is to integrate clinical findings and laboratory analyses in such a way to improve the welfare of newborn piglets and achieve better prognoses of neonatal viability. Deaths during the intrapartum period account for a significant proportion of pre-weaning mortality in farms worldwide. Piglets which die during parturition generally have normal size and typically lack gross lesions at post-mortem examination. However, circulatory abnormalities in the umbilical cord help in assessing piglet viability. Cord lesions can be classified as normal (adhered), oedematous, congested or haemorrhagic and should always be evaluated in perinatal deaths. The likelihood of neonatal survival decreases rapidly as the severity of umbilical cord lesions increase. The physiometabolic blood profile which includes acid-base balance, degree of dehydration, mineral balance, metabolic expenditure and gas exchange are also useful clinical elements for properly assessing neonatal viability. Neonatal survival is notably reduced when the blood pH falls below 7.0, lactate rises above 90 mg/dl, bicarbonate drops below 10 mmol/l, or the pCO 2 increases above 110 mm/Hg. Blood calcium is also an excellent indicator of neonatal stress when used in combination with the other parameters mentioned above. Trembling due to an imbalance in the movement of calcium in muscle is also a factor involved in neonatal mortality. Neurological function in the newborn piglet could also be evaluated by adapting the Apgar score widely used in human perinatology. Neonates with scores lower than 6 in a 10 point scale have generally lower survival rates. The two most important indicators for this vitality score are breathing latency and bradycardia. If the neonate has apnoea for more than 5 min and the cardiac frequency does not increase to more than 110 beats per minute the prognosis for survival is rather poor.

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Efficiency of Carbonyl Iron in Prevention of Anaemia in Piglets

Cited by 7 publications

References 14 publications

Peroral iron supplementation can be provided to piglets through a milk cup system with results comparable to parenteral iron administration

Peroral iron supplementation can be provided to piglets through a milk cup system with results comparable to parenteral iron administration

Iron Supplementation in Suckling Piglets: An Ostensibly Easy Therapy of Neonatal Iron Deficiency Anemia

Animal welfare in the newborn piglet: a review

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