“…In a prospective, randomized, multicenter study, sustained inflammatory response was only observed after primary intramedullary femoral instrumentation, but not after initial external fixation or after secondary conversion to an intramedullary implant [ 8 ]. In a retrospective study carried out on patients with gunshot limb trauma treated by DC surgery, DC was shown to be able to accelerate wound healing and protect against infection, which could shorten the delay of conversion from external fixation into an internal osteosynthesis [ 23 ]. In term of DC treatment for multiple trauma, it is suggested that DC can effectively reduce the mortality and complication rate, as well as shorten the ICU duration [ 24 ].…”