Efficiency of diagnostic biomarkers among colonic schistosomiasis Egyptian patients

Hamed, Manal A.; Ahmed, Samia A.; Khaled, Hussein

doi:10.1590/s0074-02762011000300011

Cited by 8 publications

(4 citation statements)

References 51 publications

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“…The variation in plasma and tissue results can be explained by induced tissue damage in the infection period, led to the release of enzyme from the necrotic tissue to blood stream or due to the increased cell anoxia and irritation by toxic or metabolic products of the worm as reported by Ahmed and Gad (1995); Hamed et al (2011). In accordance to results herein Thangaraju et al (2009);Metwally et al (2011) reported that elevation of LDH activity in malignant and bilharzial colonic carcinoma can be used as an indicator for the stimulation of anaerobic pathways in cases of abnormal growth of human cancer cells.…”

Section: Discussionmentioning

confidence: 95%

“…In general, constitutive exposure to high levels of pro-inflammatory cytokines is thought to be protumorigenic. Hamed et al (2011) reported that blood level of TNF-α was higher in colonic carcinoma associated with schistosomal infection than colonic carcinoma without schistosomal infection. These data are in accordance with Talero et al (2011) who had recorded the highest production of TNF-α in mice experimentally induced colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

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Inflammation, Oxidative Stress and L-Fucose as Indispensable Participants in Schistosomiasis-Associated Colonic Dysplasia

Soliman¹,

Keshk²,

Shoheib³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Schistosomiasis is a parasitic disease causing chronic ill health in humans with a serious consequences for socio-economic development in tropical and subtropical regions. There is also evidence linking Schistosoma mansoni to colonic carcinoma occurrence. The aim of this study was to evaluate some inflammatory and oxidative stress biomarkers, as well as L-fucose as linkers between intestinal schistosomiasis and colonic dysplasia development in mice. Materials and Methods: This study was conducted upon 80 mice that were divided the control group (10 non infected mice) and infected group which was subdivided into 7 sub-groups (10 mice each) according to the time of sacrifaction in the post infection (p.i.) period, 10 mice being sacrificed every two weeks from 6 weeks p.i. to 18 weeks p.i. Tumor necrosis factor alpha (TNF-α), inducible nitric oxide synthase (iNOS), and pentraxin 3 (PTX3) levels were estimated by immunoassay. The L-fucose level, and thioredoxin reductase (TrxR) and lactate dehydrogenase (LDH) activities were also evaluated in colonic tissue. Results: The current study revealed statistically significant elevation in the studied biochemical markers especially at 16 and 18 weeks p.i. The results were confirmed by histopathological examination that revealed atypical architectural and cytological changes in the form of epithelial surface serration and nuclear hyper-chromatizia at 14, 16 and 18 weeks p.i. Conclusions: inflammation, oxidative stress and L-fucose together may form an important link between Schistosomal mansoni infection and colonic dysplasia and they can be new tools for prediction of colonic dysplasia development in experimental schistosomiasis.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Inflammation, Oxidative Stress and L-Fucose as Indispensable Participants in Schistosomiasis-Associated Colonic Dysplasia

Soliman¹,

Keshk²,

Shoheib³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Also, inflammation also exacerbates the development of liver injury. Nuclear factor-kappa B (NF-κB), an inducible transcription factor with pleiotropic functions, is critically involved in the occurrence and development of inflammation which actively participates in the transcription of many pro-inflammatory factors, including interleukin 1β (IL-1β) and tumor necrosis factor-α (TNF-α) [17] , [18] . However, the exact relationship between Cr(VI)-induced liver injury and inflammation, as well as apoptosis has not yet been elucidated.…”

Section: Introductionmentioning

confidence: 99%

The link between deacetylation and hepatotoxicity induced by exposure to hexavalent chromium

Yang

Han

et al. 2022

Journal of Advanced Research

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“…Other helminth-derived molecules are unique to the parasites and help them initiate tissue damage and establish infection (Periago and Bethony, 2012;Flynn et al, 2019). Such helminth-specific biomolecules have also been explored widely as biomarkers for developing diagnostics and targets for developing vaccines and drugs (Hamed et al, 2011;Ryan et al, 2020;Whitman et al, 2021). Numerous reviews (McSorley et al, 2013;Maizels and McSorley, 2016;Maizels et al, 2018;Zakeri et al, 2018;Ryan et al, 2020) have substantially discussed the nature and functions of many helminth-derived macromolecules, including secreted proteins, peptides, and extracellular vesicles.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory and biological properties of helminth-derived small molecules: Potential applications in diagnostics and therapeutics

et al. 2022

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Parasitic helminths secrete and excrete a vast array of molecules known to help skew or suppress the host’s immune response, thereby establishing a niche for sustained parasite maintenance. Indeed, the immunomodulatory potency of helminths is attributed mainly to excretory/secretory products (ESPs). The ESPs of helminths and the identified small molecules (SM) are reported to have diverse biological and pharmacological properties. The available literature reports only limited metabolites, and the identity of many metabolites remains unknown due to limitations in the identification protocols and helminth-specific compound libraries. Many metabolites are known to be involved in host-parasite interactions and pathogenicity. For example, fatty acids (e.g., stearic acid) detected in the infective stages of helminths are known to have a role in host interaction through facilitating successful penetration and migration inside the host. Moreover, excreted/secreted SM detected in helminth species are found to possess various biological properties, including anti-inflammatory activities, suggesting their potential in developing immunomodulatory drugs. For example, helminths-derived somatic tissue extracts and whole crude ESPs showed anti-inflammatory properties by inhibiting the secretion of proinflammatory cytokines from human peripheral blood mononuclear cells and suppressing the pathology in chemically-induced experimental mice model of colitis. Unlike bigger molecules like proteins, SM are ideal candidates for drug development since they are small structures, malleable, and lack immunogenicity. Future studies should strive toward identifying unknown SM and isolating the under-explored niche of helminth metabolites using the latest metabolomics technologies and associated software, which hold potential keys for finding new diagnostics and novel therapeutics.

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Efficiency of diagnostic biomarkers among colonic schistosomiasis Egyptian patients

Cited by 8 publications

References 51 publications

Inflammation, Oxidative Stress and L-Fucose as Indispensable Participants in Schistosomiasis-Associated Colonic Dysplasia

Inflammation, Oxidative Stress and L-Fucose as Indispensable Participants in Schistosomiasis-Associated Colonic Dysplasia

The link between deacetylation and hepatotoxicity induced by exposure to hexavalent chromium

Immunomodulatory and biological properties of helminth-derived small molecules: Potential applications in diagnostics and therapeutics

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