Efficiency of domestic preparation cytoflavin for prevention of clinical stage of cardiomyopathy overvoltage

Василенко, Владимир Станиславович; Lopatin, Z.V.; Karpovskaya, Ekaterina B.; Semenova, Yu.B.

doi:10.17116/profmed202023031113

Cited by 3 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Во время эпидемии новой коронавирусной инфекции особое значение приобрело применение препарата для профилактики синдрома полиорганной недостаточности у пациентов с тяжелым течением COVID-19. Основанием для применения являются не только системное антигипоксическое действие сукцината, характерное также для препаратов Реамберин® и Ремаксол® того же производителя, нашедших применение в клинической практике при этом заболевании [81-83], но и более выраженное влияние Цитофлавина® на эндотелий-зависимые звенья патогенеза [84,85] Исследовалось применение Цитофлавина® при заболеваниях сердечно-сосудистой системы [92][93][94]. Показано, что курсовое применение таблетированной формы Цитоф-лавина® оказывает положительное влияние на процессы ремоделирования миокарда, а также на функцию эндотелия, предотвращая развитие эндотелиальной дисфункции.…”

Section: анализ результатов клинического применения цитофлавина® при ...unclassified

Pathogenetic and pharmacodynamic features of succinic acid derivative application for various diseases of the cardiovascular and nervous systems

Kim,

Shustov,

Ganapolsky

2024

Psychopharmacology & biological narcology

View full text Add to dashboard Cite

This study revealed the pathogenetic patterns of the development of hypoxic and ischemic disorders in various pathological conditions and substantiated approaches to the use of drugs with antihypoxic activity. The role of the receptor interaction of succinic acid in the composition of succinate-containing antihypoxants with succinate receptor SUCNR1 has been demonstrated. The pharmacodynamic properties of the combined preparation of succinic acid that also contains vitamin precursors of the cofactors of Krebs cycle dehydrogenases nicotinamide (precursor of NAD) and riboflavin mononucleotide (precursor of FAD) and precursor of purine nucleotides (inosine) (cytoflavin) for intravenous drip and oral administration were analyzed. Literature data were also analyzed to evaluate the effectiveness of the use of the metabolic corrector of energy-dependent and hypoxic conditions (cytoflavin) in various central nervous system and cardiovascular diseases. In the case of ischemic disorders of cerebral and coronary blood flow, the effects of the drug are concentrated on the penumbra zone (ischemic penumbra), which is associated with the intravenous administration of the drug to its metabolic activity by influencing endothelial cells, restoring microcirculation, and enhancing the oxygen transport function of the blood. Among the new areas of drug use, the use of cytoflavin in the complex therapy of traumatic brain injuries, traumatic shock, acute respiratory distress syndrome, toxic lesions of the central nervous system, multiple organ failure syndrome, and post-COVID syndrome is promising.

show abstract

Section: анализ результатов клинического применения цитофлавина® при ...unclassified

Pathogenetic and pharmacodynamic features of succinic acid derivative application for various diseases of the cardiovascular and nervous systems

Kim,

Shustov,

Ganapolsky

2024

Psychopharmacology & biological narcology

View full text Add to dashboard Cite

show abstract

Mexidol, Cytoflavin, and succinic acid derivatives as antihypoxic, anti‐ischemic metabolic modulators, and ergogenic aids in athletes and consideration of their potential as performance enhancing drugs

Jędrejko,

Catlin,

Stewart

et al. 2024

Drug Testing and Analysis

View full text Add to dashboard Cite

Emoxypine (ethylmethylhydroxypyridine) is a synthetic derivative of vitamin B6. Emoxypine succinate is a registered drug in Russia and Ukraine under various trade names including Mexidol, Mexicor, and Armadin Long. Mexidol demonstrates antihypoxic and anti‐ischemic effects and also modulates metabolism. The use of Mexidol by Russian athletes has been confirmed in the past. Current use by athletes is unknown as this drug is not monitored or included in drug testing protocol. Metabotropic and antihypoxic effects of Mexidol were compared to the effects of meldonium or trimetazidine, both of which are included on the World Anti‐Doping Agency (WADA) Prohibited List in category S4.4. Metabolic Modulators. The conjugation of emoxypine with succinate elevates the therapeutic effectiveness of the Mexidol formulation as succinic acid itself has important impacts to consider despite being a common food additive and drug excipient. Other succinic acid salts like ammonium succinate, found as dietary supplement, have been patented as performance enhancers. Available research on healthy subjects suggests that combinations of selected 3‐substituted pyridine derivatives with succinate including Mexidol and a related drug Cytoflavin can enhance the performance of athletes. Cytoflavin is a multi‐component formula containing meglumine sodium succinate, nicotinamide (vitamin B3), inosine (riboxin), and riboflavin. Other related succinate‐based drugs include Remaxol, Reamberin, and Cogitum. Mexidol and Cytoflavin and related substances exhibit similar biological effects as drugs on the WADA Prohibited List, and if they are used for performance enhancement by athletes, they could be worthy of consideration as prohibited substances in sport.

show abstract

Effectiveness of the second stage program of medical rehabilitation of patients with ischemic heart disease

Grishechkina,

Fesyun,

Yakovlev

et al. 2024

Rus. J. Prev. Med.

View full text Add to dashboard Cite

Efficiency of domestic preparation cytoflavin for prevention of clinical stage of cardiomyopathy overvoltage

Cited by 3 publications

References 17 publications

Pathogenetic and pharmacodynamic features of succinic acid derivative application for various diseases of the cardiovascular and nervous systems

Pathogenetic and pharmacodynamic features of succinic acid derivative application for various diseases of the cardiovascular and nervous systems

Mexidol, Cytoflavin, and succinic acid derivatives as antihypoxic, anti‐ischemic metabolic modulators, and ergogenic aids in athletes and consideration of their potential as performance enhancing drugs

Effectiveness of the second stage program of medical rehabilitation of patients with ischemic heart disease

Contact Info

Product

Resources

About