Efficiency of four solutions in removing 23 conventional antineoplastic drugs from contaminated surfaces

Simon, Nicolas; Guichard, Nicolas; Odou, Pascal; Décaudin, Bertrand; Bonnabry, Pascal; Fleury-Souverain, Sandrine

doi:10.1371/journal.pone.0235131

Cited by 10 publications

(4 citation statements)

References 37 publications

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“…According to recent surveys, cyclophosphamide (CP) (classified as carcinogenic to humans by the International Research on Cancer, IARC), ifosfamide (IF), methotrexate (MTX), gemcitabine (GEM), 5–fluorouracil (5–FU), irinotecan (IRT), etoposide (ETP), taxanes (TX), and vinorelbine (VNR) are the most used ADs [ 3 , 4 , 5 , 6 ]. The literature has seen a number of papers being published with a focus on several issues regarding the topic of occupational exposure to ADs [ 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. As a matter of concern, to evaluate the entire workplace and to define a proper protection level for hospital personnel, measures to limit the spread of contamination are continuously taken by practitioners.…”

Section: Introductionmentioning

confidence: 99%

Occupational Exposure Assessment to Antineoplastic Drugs in Nine Italian Hospital Centers over a 5-Year Survey Program

Sottani

Grignani

Cornacchia

et al. 2022

IJERPH

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In the present study, surface contamination where antineoplastic drugs (ADs) are present was investigated, as occupational exposure risk is still an open debate. Despite recommendations and safety standard procedures being in place in health care settings, quantifiable levels of ADs are being reported in the recent literature. Thus, a survey monitoring program was conducted over five years (2016–2021) in nine Italian hospitals. The repeated surveys produced 8288 data points that have been grouped according to the main hospital settings, such as pharmacy areas and patient care units. Based on the most often prepared ADs, the investigated drugs were cyclophosphamide (CP), gemcitabine (GEM), 5-fluorouracil (5–FU), and platinum compounds (Pt). Patient care units had a frequency of positive wipe samples (59%) higher than pharmacies (44%). Conversely, pharmacies had a frequency of positive pad samples higher (24%) than patient care units (10%). Moreover, by statistical analysis, pad samples had a significantly higher risk of contamination in pharmacy areas than in patient care units. In this study, the 75th and the 90th percentiles of the contamination levels were obtained. The 90th percentile was chosen to describe a suitable benchmark that compares results obtained by the present research with those previously reported in the literature. Based upon surface contamination loads, our data showed that 5–FU had the highest concentration values, but the lowest frequency of positive samples. In pharmacy areas, the 90th percentile of 5–FU data distribution was less than 0.346 ng/cm2 and less than 0.443 ng/cm2 in patient care units. AD levels are higher than those reported for health care settings in other European countries yet trends of contamination in Italy have shown to decrease over time.

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Section: Introductionmentioning

confidence: 99%

Occupational Exposure Assessment to Antineoplastic Drugs in Nine Italian Hospital Centers over a 5-Year Survey Program

Sottani

Grignani

Cornacchia

et al. 2022

IJERPH

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“…Update of cleaning procedures, including alternative or additional cleaning agents, may reduce the antibiotic surface contamination but requires assessment of its effectiveness as performed for hazardous drugs. 38 Ultimately, implementation of engineering controls such as CSTDs or similar devices may provide the most effective method to reduce or eliminate the environmental contamination and the exposure risk. As no specific official regulations for antibiotics exist, it is recommended that legal authorities and professional organizations of hospital pharmacists and nurses take the initiative to develop these to ensure safety of the healthcare workers.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of environmental antibiotic contamination by surface wipe sampling in a large care centre

Sessink,

Tans,

Devolder

et al. 2024

Journal of Antimicrobial Chemotherapy

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Objectives Exposure of healthcare workers to antibiotics may cause adverse health effects. Results of environmental contamination with antibiotics, obtained by taking surface wipe samples, can be used as an indicator for potential exposure to these sensitizing drugs. The objective was to describe the results of repeated measurements of contamination with antibiotics on multiple surfaces in hospital wards. Standardized needle and syringe preparation techniques and cleaning procedures were used. Methods The preparation table and the floor around the waste bin in six wards were sampled and analysed for contamination with the antibiotics amoxicillin, benzylpenicillin, cefotaxime, ceftriaxone, flucloxacillin, meropenem, piperacillin and vancomycin. Sampling was performed in four trials during 8 months. Depending on the outcome of the trials, the cleaning procedure was adapted. Liquid chromatography with tandem mass spectrometry was used for the analysis of the drugs. Results During the four trials, contamination with all eight antibiotics was omnipresent on all preparation tables and floors in the six wards. The highest contamination was found for amoxicillin (1291 ng/cm2). Changing the cleaning procedure did not reduce the level of contamination. Conclusions Surface contamination with the antibiotics was widespread and most probably caused by spillage during the preparation in combination with an ineffective cleaning procedure. Strategies should be developed and implemented by institutions for safe handling of antibiotics to reduce environmental contamination and potential exposure of healthcare workers to these sensitizing drugs.

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“…Hal ini membantu menstrerilkan residu obat kemoterapi tersebut. Selain cairan pembersih toilet, berdasarkan hasil penelitian Simon et al, (2020), cairan yang mengadung sodium hypochlorite efisien sebagai dekontaminan pada berbagai obat kemoterapi. Dan sodium hypochlorite ini banyak terdapat pada pemutih pakaian.…”

Section: Pembahasanunclassified

Pencegahan Keluarga Pasien Kanker Terhadap Paparan Obat Kemoterapi

Indra¹,

Mufathuzzahra

Daniati

2022

J Keskom

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Obat sitotoksik tidak hanya berpengaruh terhadap pasien kanker yang menerima kemoterapi, namun juga terhadap anggota keluarga yang melakukan kontak erat dengan pasien baik selama perawatan ataupun setelah pasien di rumah. Tujuan penelitian ini untuk mengidentifikasi tindakan pencegahan yang dilakukan keluarga pasien untuk menghindari paparan terhadap obat kemoterapi setelah pasien sampai di rumah. Penelitian deskriptif dilakukan dengan sampel 84 orang keluarga pasien yang menjalani kemoterapi yang diambil dengan teknik consecutive sampling. Pengumpulan data menggunakan kuesioner dan diolah menggunakan distribusi frekuensi. Hasil penelitian ditemukan 58,3% pasien tidak tinggal serumah dan atau menghindari kontak dengan anak-anak, ibu hamil dan lansia; 39,3% keluarga menggunakan toilet yang berbeda dengan pasien; 85,7% keluarga menyiram toilet menggunakan cairan pembersih toilet setelah digunakan pasien; 78,6% keluarga melakukan penggantian alas kasur minimal sekali 3 hari; 70,2% keluarga menggunakan sarung tangan sekali pakai saat mencuci pakaian pasien dan sebanyak 84,5% keluarga menyediakan tempat muntahan khusus. Diharapkan perawat mengedukasi pasien dan keluarganya mengenai pencegahan pajanan terhadap obat kemoterapi di rumah.

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Efficiency of four solutions in removing 23 conventional antineoplastic drugs from contaminated surfaces

Abstract: Background Residual contamination by intravenous conventional antineoplastic drugs (ICAD) is still a daily issue in hospital facilities. This study aimed to compare the efficiency (Eff Q) of 4 different solutions to remove 23 widely used ICADs from surfaces.

Cited by 10 publications

References 37 publications

Occupational Exposure Assessment to Antineoplastic Drugs in Nine Italian Hospital Centers over a 5-Year Survey Program

Occupational Exposure Assessment to Antineoplastic Drugs in Nine Italian Hospital Centers over a 5-Year Survey Program

Evaluation of environmental antibiotic contamination by surface wipe sampling in a large care centre

Pencegahan Keluarga Pasien Kanker Terhadap Paparan Obat Kemoterapi

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