Efficiency of ginger (Zingbar officinale) against Schistosoma mansoni infection during host–parasite association

Aly, Hanan F.; Mantawy, Mona M.

doi:10.1016/j.parint.2013.04.002

Cited by 35 publications

(24 citation statements)

References 31 publications

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“…Worms were recovered from the hepatic portal system and liver by a perfusion technique described by Aly and Mantawy [21]. The worms from each mouse were left to sediment for approximately 20 min in a small Petri dish to allow sex identification, examination and counting.…”

Section: Methodsmentioning

confidence: 99%

Ceratonia siliqua pod extract ameliorates Schistosoma mansoni-induced liver fibrosis and oxidative stress

Al-Olayan

El‐Khadragy

Alajmi

et al. 2016

BMC Complement Altern Med

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BackgroundSchistosomiasis is a prevalent parasitic disease found predominantly in tropical and sub-tropical areas of the developing world, with the second highest socioeconomic and public health burden despite strenuous control efforts. In the present study, we aimed to investigate the ameliorative effects of Ceratonia siliqua pod extract (CPE) on liver fibrosis and oxidative stress in mice infected with Schistosoma mansoni.MethodsThe schistosomal hepatopathologic mouse model was established by tail immersion with schistosomal cercaria. The extract was given daily for 10 days beginning 42 days post-infection. Liver samples were obtained from mice sacrificed 9 weeks after infection. Liver histopathological changes were observed with hematoxylin-eosin and Masson trichrome staining.ResultsTypical schistosomal hepatopathologic changes were induced in the untreated mice. However, the oral administration of CPE was effective in reducing worm number and the egg load in the liver. This treatment also decreased granuloma size and collagen deposition by inhibiting tissue inhibitor of metalloproteinases-2 (TIMP-2) expression. Schistosomal infection induced oxidative stress by increasing lipid peroxidation (LPO) and nitrite/nitrate (nitric oxide; NO) production along with concomitant decreases in glutathione (GSH) and various antioxidant enzymes, including superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase. However, treatment of mice with CPE at 300 or 600 mg/kg inhibited LPO and NO production, increased GSH content, and restored the activities of the antioxidant enzymes compared with untreated infected mice. Furthermore, treatment with CPE inhibited apoptosis, as indicated by the reduced Bax expression in hepatic tissue.ConclusionThese data indicated that extracts from Ceratonia siliqua pods may play an important role in combating schistosomal hepatopathology and may inhibit granuloma formation and liver fibrosis through down-regulation of TIMP-2 expression.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1389-1) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Ceratonia siliqua pod extract ameliorates Schistosoma mansoni-induced liver fibrosis and oxidative stress

Al-Olayan

El‐Khadragy

Alajmi

et al. 2016

BMC Complement Altern Med

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“…onions, garlic, chives, coconut, birch bark, pineapple, banana, mangosteen, chicory, date palm fruit, fig, pumpkin, and neem tree seeds against nematodes (Trichuris muris and Angiostrongylus cantonensis) (Klimpel et al, 2011) and trematodes (Fasciola hepatica and Echinostoma caproni) . Other studies have reported on the effects of ginger (Zingiber officinale) on different stages of Schistosoma mansoni (Aly and Mantawy, 2013;Mostafa et al, 2011), and the effects of water extract of black nightshade (Solanum nigrum) leaves on Schistosoma mansoni (Ahmed and Rifaat, 2005). Piper chaba fruits demonstrated strong activity against schistosome cercariae (Atjanasuppat et al, 2009), while Lysimachia ramosa Wall.…”

Section: Introductionmentioning

confidence: 99%

Anthelmintic, anti-inflammatory and antioxidant effects of Garcinia mangostana extract in hamster opisthorchiasis

Aukkanimart

Boonmars

Sriraj

et al. 2015

Experimental Parasitology

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“…Determination of enzyme levels, such as serum AST and ALT is largely used during the assessment of liver damage by schistosomal infection (Aly and Mantawy, 2013;Al-Sayed et al, 2014). Necrosis or membrane damage releases the enzymes into circulation; therefore, they can be measured in the serum.…”

Section: Discussionmentioning

confidence: 99%

The potential role of mefloquine against Schistosoma mansoni infection by prohibition of hepatic oxidative stress in mice

Fahmy

Rabia

Mansour

2014

The Journal of Basic & Applied Zoology

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The present study was designed to assess the relationship between anti-schistosomal effect of the antimalarial drug mefloquine (Mef) and the oxidative stress status of Schistosoma mansoni infected mice. Forty mice were divided into eight groups (5 mice/group); control (I, II), infected (III, IV), Mef low dosage (200 mg/kg) (V, VI), and Mef high dosage (400 mg/kg) (VII, VIII). Mef (200 and 400 mg/kg) was administered orally as a single dose at days 14 and 35 post infection (PI). All mice were sacrificed after 8 weeks PI. Oral administration of Mef (200 or 400 mg/kg) at day 14 or 35 PI reduced the total worm burden by 84%, 78% and 94%, 85.7% respectively. Meanwhile, Mef treatment reduced egg load in the intestine and the liver. Following Mef (200 and 400 mg/kg) treatment to mice at day 14 or 35 PI, the oogram pattern showed complete disappearance of all immature and mature ova. Treatment of mice with Mef at the two tested doses significantly decreased the activities of ALT, AST, ALP and GGT enzymes as compared to infected untreated group. However, administration of Mef (200 and 400 mg/kg) at day 14 or 35 PI significantly (P < 0.05) decreased the MDA level and increased the levels of GSH and CAT as compared to infected untreated group. In conclusion, Mef is an effective curative anti-schistosomal and anti-oxidative drug as it alleviates the biochemical and the oxidative stress alterations. Also, Mef has schistosomicidal and ovicidal effects.

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Efficiency of ginger (Zingbar officinale) against Schistosoma mansoni infection during host–parasite association

Cited by 35 publications

References 31 publications

Ceratonia siliqua pod extract ameliorates Schistosoma mansoni-induced liver fibrosis and oxidative stress

Ceratonia siliqua pod extract ameliorates Schistosoma mansoni-induced liver fibrosis and oxidative stress

Anthelmintic, anti-inflammatory and antioxidant effects of Garcinia mangostana extract in hamster opisthorchiasis

The potential role of mefloquine against Schistosoma mansoni infection by prohibition of hepatic oxidative stress in mice

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