Efficiency of Helicobacter pylori Infection Treatment Protocol: Clarithromycin, Amoxicillin and Omeprazole

Abstract

Implication for health policy/practice/research/medical education: Clarithromycin, Amoxicillin and Omeprazole for treatment of H. pylori infection can be useful which is concluded from lower levels of IgG and CagA in blood and H. pylori antigen in stool after treatment compared to the amount of these factors before therapy. Copyright © 2013, Infectious Diseases and Tropical Medicine Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. BackgroundHelicobacter pylori (H. pylori) is a gram negative, spiral and flagella bacteria, colonized in the mucosa of stomach which has an important etiologic role in gastric diseases especially gastric ulcers (1). H. pylori is one of the most common pathogens affecting humans, which approximately infects 50% of the world population that remains as a significant cause of morbidity and mortality (2). Several studies have shown the relationship among this organism and some other gastric diseases such as ischemic heart disease, idiopathic thrombocytopenic purpura, and iron deficiency anemia, etc. (3). Recent evidences demonstrate that H. pylori has an important role in some of the skin diseases progression, e.g. Reynaud's disease, Rosacea, prurigo nodular is atopic dermatitis and chronic urticaria (4, 5). H. pylori is a very common infection which occurs at young ages in developing countries. One of the significantly independent risk factors for infection is low socioeconomic status (6). Many epiddemiologic studies of H. pylori have confirmed that the infection to this bacterium is observed among children in developing countries, which may be due to bad household hygiene and sanitation (7-9). Furthermore, these studies about H. pylori transmission showed that the majority of infections tend to occur within families through close person-to-person contact (10). H. pylori infection seems to be transmitted most readily among siblings who are in Background: Helicobacter pylori (H. pylori) is one of the most common pathogen affecting humans, which is approximately infecting 50% of the world population and remains as a significant cause of morbidity and mortality. Since the discovery of Helicobacter pylori in early 1980, many treatment regimens have been developed to effectively treat this infection. Despite the extensive research over the last 25 years the treatment of Helicobacter pylori remains a challenging clinical problem due to its antimicrobial resistance. Objectives: This study aimed to evaluate Clarithromycin, Amoxicillin and Omeprazole efficiency as a treatment for H. pylori. Patients and Methods:The patients with clinical features of H. pylori infection and positive serological and clinical test results were entered to the study. Whole of the patients enrolled in the study were given a full two weeks of effective treatment protocol of H. pylori consisted of Clarithromycin (20 mg PO bid), A...

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