Matrix rhythm therapy (MRT) is an advanced electrotherapeutic modality, which works on mechanical and magnetic vibrations and delivers physiological rhythmical oscillations, whose frequency changes according to the individuals’ tissue requirement that synchronizes with internal body rhythm. The aim of the study is to find in which conditions MRT can be effective with or without conventional physiotherapy. Databases used were Google scholar, PubMed, with keywords MRT advance physiotherapy. Studies published in English, original articles from 2018 to 2023 were included. All types of studies were included: systemic reviews, reviews, randomized controlled trials (RCTs), case series, and case report. Duplicate and irrelevant articles were excluded. Fifteen articles were found of which 9 studies were included. In this study, 1 systemic review, 1 review, 3 RCT, 1 case series, and 3 case reports were there. However, MRT with conventional physiotherapy was found to be superior in reducing pain and improving range of motion, strength, balance, gait parameters, muscle tone, strength, and quality of life. MRT may show great effects in decreasing spasticity when used with other conventional physical therapy. This brief study found that the MRT is effective, which exists as new development in the stream of physiotherapy. MRT is a recent tool in rehabilitation that is being used in conditions such as chronic back and neck pain, frozen shoulder, stroke, plantar fasciitis, decubitus ulcer, trigeminal neuralgia, oral submucous fibrosis, burns, and lymphedema.