Efficiency of Nanomaterials for Electrochemical Diagnostics based Point-of-Care Detection of Non-Invasive Oral Cancer Biomarkers

Kumar, Neeraj; Khan, V. Sorna Gowri;Raju; Ranjan, Pushpesh; Sadique, Mohd Abubakar; Yadav, Shalu; Singhal, Ayushi; Mishra, Alka; Murali, S

doi:10.5185/amlett.2021.081651

Cited by 12 publications

(12 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tumor heterogenicity can be identified using reliable biomarkers. A biomarker is an abbreviation for biological markers associated with a specific disease, and it is measured as an indicator of the extent of clinical diseases [ 20 , 70 ]. The presence of a biomarker in blood or any other body fluid or tissues indicates the particular condition of disease [ 71 ].…”

Section: Potential Biomarkers Associated With Cancermentioning

confidence: 99%

“…Various other analytical techniques such as polymerase chain reaction (PCR), immunohistochemistry, flow cytometry have been used for the evaluation of cancer biomarkers; however, they lack acceptable sensitivity and need sophisticated instrumentation facilities with long run time. Biosensors-based detection of biomarkers can be used efficiently for the early diagnosis of cancer disease [ 15 , 20 , 23 ]. The use of biorecognition elements (BREs) such as an antibody, aptamers, enzymes with conjugation to biomarkers associated with cancer cells enhanced the selectivity and sensitivity of the detection technique [ 82 ].…”

Section: Potential Biomarkers Associated With Cancermentioning

confidence: 99%

“…Recently, biosensors-based advanced diagnostic approaches have shown potential for the early diagnosis of cancer and other deadly diseases [ 6 , 16 , 17 ]. Several techniques employed for the detections are optical [ 18 , 19 ], electrochemical [ 20 , 21 ], and piezoelectric [ 22 ]. The electrochemical-based detection of several biomarkers such as EpCAM, CD44, VEGF, Mucin 1, CEA has fetched great attention [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Next-Generation Intelligent MXene-Based Electrochemical Aptasensors for Point-of-Care Cancer Diagnostics

et al. 2022

Self Cite

View full text Add to dashboard Cite

Delayed diagnosis of cancer using conventional diagnostic modalities needs to be addressed to reduce the mortality rate of cancer. Recently, 2D nanomaterial-enabled advanced biosensors have shown potential towards the early diagnosis of cancer. The high surface area, surface functional groups availability, and excellent electrical conductivity of MXene make it the 2D material of choice for the fabrication of advanced electrochemical biosensors for disease diagnostics. MXene-enabled electrochemical aptasensors have shown great promise for the detection of cancer biomarkers with a femtomolar limit of detection. Additionally, the stability, ease of synthesis, good reproducibility, and high specificity offered by MXene-enabled aptasensors hold promise to be the mainstream diagnostic approach. In this review, the design and fabrication of MXene-based electrochemical aptasensors for the detection of cancer biomarkers have been discussed. Besides, various synthetic processes and useful properties of MXenes which can be tuned and optimized easily and efficiently to fabricate sensitive biosensors have been elucidated. Further, futuristic sensing applications along with challenges will be deliberated herein.

show abstract

Section: Potential Biomarkers Associated With Cancermentioning

confidence: 99%

Section: Potential Biomarkers Associated With Cancermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Next-Generation Intelligent MXene-Based Electrochemical Aptasensors for Point-of-Care Cancer Diagnostics

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…had concluded more than 100 salivary potential biomarkers (DNA, RNA, mRNA, protein markers) as early diagnostic markers for oral cancer, including cytokines (IL-8, IL-1β, TNF-α), defensin-1, P53, Cyfra 21–1, tissue polypeptide specific antigen, dual-specificity phosphatase, spermidine/spermineN1-acetyltransferase, profilin, cofilin-1, transferrin, osteopontin, and many more [ 3 , [84] , [85] , [86] ]. A recent review summarized 65 salivary-based biomarkers and their function in oral cancer [ 87 ]. In addition to the above summary, long non-coding RNAs can also be used as potential markers for oral cancer diagnosis [ 88 ].…”

Section: Application Of Aunps In Oral Cancer Diagnosismentioning

confidence: 99%

Gold nanomaterials for oral cancer diagnosis and therapy: Advances, challenges, and prospects

Zhang

Hou

Wen

et al. 2022

Materials Today Bio

View full text Add to dashboard Cite

“…Therefore, screening of cancer at the early stage becomes more significant to control the disease progression as well as for treatment [ 154 , 155 ]. In this perspective, numerous highly sensitive, specific, and reproducible biosensors have been reported for the diagnosis of cancer biomarkers [ 156 , 157 ]. For instance, Huang et al reported an aptamer-based biosensor for the detection of carcinoembryonic antigen (CEA) biomarker at femtogram concentration with high sensitivity.…”

Section: Ionic Liquids–carbon-based Functional Nanomaterials In Biosensing Applicationsmentioning

confidence: 99%

Functional Ionic Liquids Decorated Carbon Hybrid Nanomaterials for the Electrochemical Biosensors

et al. 2021

Self Cite

View full text Add to dashboard Cite

Ionic liquids are gaining high attention due to their extremely unique physiochemical properties and are being utilized in numerous applications in the field of electrochemistry and bio-nanotechnology. The excellent ionic conductivity and the wide electrochemical window open a new avenue in the construction of electrochemical devices. On the other hand, carbon nanomaterials, such as graphene (GR), graphene oxide (GO), carbon dots (CDs), and carbon nanotubes (CNTs), are highly utilized in electrochemical applications. Since they have a large surface area, high conductivity, stability, and functionality, they are promising in biosensor applications. Nevertheless, the combination of ionic liquids (ILs) and carbon nanomaterials (CNMs) results in the functional ILs-CNMs hybrid nanocomposites with considerably improved surface chemistry and electrochemical properties. Moreover, the high functionality and biocompatibility of ILs favor the high loading of biomolecules on the electrode surface. They extremely enhance the sensitivity of the biosensor that reaches the ability of ultra-low detection limit. This review aims to provide the studies of the synthesis, properties, and bonding of functional ILs-CNMs. Further, their electrochemical sensors and biosensor applications for the detection of numerous analytes are also discussed.

show abstract

Efficiency of Nanomaterials for Electrochemical Diagnostics based Point-of-Care Detection of Non-Invasive Oral Cancer Biomarkers

Cited by 12 publications

References 108 publications

Next-Generation Intelligent MXene-Based Electrochemical Aptasensors for Point-of-Care Cancer Diagnostics

Next-Generation Intelligent MXene-Based Electrochemical Aptasensors for Point-of-Care Cancer Diagnostics

Gold nanomaterials for oral cancer diagnosis and therapy: Advances, challenges, and prospects

Functional Ionic Liquids Decorated Carbon Hybrid Nanomaterials for the Electrochemical Biosensors

Contact Info

Product

Resources

About