Efficiency of propofol versus midazolam and fentanyl sedation at a pediatric teaching hospital: a prospective study

Lightdale, Jenifer R.; Valim, Clarissa; Newburg, Adrienne; Mahoney, Lisa B.; Zgleszewski, Steven E.; Fox, Victor L.

doi:10.1016/j.gie.2007.11.038

Cited by 38 publications

(30 citation statements)

References 31 publications

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“…Similar findings have been reported in studies evaluating sedation in children when propofol is administered 3,6,10,12,18. While this study is the first to compare the efficacy and safety of IV administered midazolam and propofol for sedation in children during endoscopic procedures in Korea, our study has limitations of a retrospective single-center study with small sample size.…”

Section: Discussionsupporting

confidence: 75%

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Propofol versus Midazolam for Sedation during Esophagogastroduodenoscopy in Children

Lee

2013

Clin Endosc

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Background/AimsTo evaluate the efficacy and safety of propofol and midazolam for sedation during esophagogastroduodenoscopy (EGD) in children.MethodsWe retrospectively reviewed the hospital records of 62 children who underwent ambulatory diagnostic EGD during 1-year period. Data were collected from 34 consecutive patients receiving propofol alone. Twenty-eight consecutive patients who received sedation with midazolam served as a comparison group. Outcome variables were length of procedure, time to recovery and need for additional supportive measures.ResultsThere were no statistically significant differences between the two groups in age, weight, sex, and the length of endoscopic procedure. The recovery time from sedation was markedly shorter in propofol group (30±16.41 minutes) compared with midazolam group (58.89±17.32 minutes; p<0.0001). During and after the procedure the mean heart rate was increased in midazolam group (133.04±19.92 and 97.82±16.7) compared with propofol group (110.26±20.14 and 83.26±12.33; p<0.0001). There was no localized pain during sedative administration in midazolam group, though six patients had localized pain during administration of propofol (p<0.028). There was no serious major complication associated with any of the 62 procedures.ConclusionsIntravenous administered propofol provides faster recovery time and similarly safe sedation compared with midazolam in pediatric patients undergoing upper gastrointestinal endoscopy.

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Section: Discussionsupporting

confidence: 75%

“…Being a rapid acting sedative agent with minimal recovery time, propofol is a very effective sedative in children who are undergoing gastrointestinal (GI) endoscopy 3,4. It also has antiemetic and amnestic effect.…”

Section: Introductionmentioning

confidence: 99%

Propofol versus Midazolam for Sedation during Esophagogastroduodenoscopy in Children

Lee

2013

Clin Endosc

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“…Los fármacos utilizados con mayor frecuencia para la sedación son benzodiazepinas, opiodes y ketamina, los que generalmente deben combinase para lograr el nivel de sedación deseada 4,8 . Recientemente se ha descrito con éxito el uso de propofol en diferentes procedimientos [9][10][11] . En un estudio prospectivo, Lightdale y cols, evaluaron el uso de propofol como agente para sedación en procedimientos endoscópicos en niños, sin embargo, al compararlo con agentes de uso común como midazolam y fentanilo, no observaron mayores beneficios 11 .…”

Section: Discussionunclassified

Sedación, Seguridad y Utilidad de la Endoscopia Digestiva Alta en Pediatría

et al. 2010

Rev. chil. pediatr.

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Introduction:Upper gastrointestinal studies are routine diagnostic and therapeutic procedures. In pediatrics, however, they are limited by the need for sedation and monitoring. Objectives: To evaluate sedation, indication, and parent perception of these exams. Patients and Methods: A prospective study of 190 pediatric upper gastrointestinal endoscopies was undertaken. Demographic data, as well as information regarding the exam was obtained. Results: Patients' average age was 8.5 ± 4.2, mostly referred by pediatricians (60%) Main reason for referral was recurrent abdominal pain (29.8%). Patients were classified according to ASA criteria (93% ASA I and II). Most patients required two or more medications for optimal sedation, with satisfactory procedure in over 90%. Over 75.5% had complete amnesia, 42.7% presented minor discomfort after the procedure. Findings of these procedures included 61% of normal exams, 13.9% esophagitis. More findings were there result of analyses according to children's weight (over or under 14 kg), age, ASA, reason for referral, nurse's evaluation of sedation. Conclusion: Ambulatory endoscopic procedures can be performed safely in children, with moderate sedation. Requirements are adequate monitoring, and deep knowledge of resuscitation techniques.

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“…Therefore, the administration of propofol had been restricted primarily to anesthesiologists and trained nurse anesthetists in order to manage airway in emergency. However, propofol has been noticed on account of the rapid time to onset and recovery time, in addition to the better or similar patient satisfaction [32,33]. Some recent studies suggest that propofol can be safely administered to children by nonanesthesiologists who specifically trained to follow established safety guideline [31].…”

Section: Sedative Agents For Children Undergoing Endoscopymentioning

confidence: 99%

Sedation for Pediatric Endoscopy

Lee

2014

Pediatr Gastroenterol Hepatol Nutr

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It is more difficult to achieve cooperation when conducting endoscopy in pediatric patients than adults. As a result, the sedation for a comfortable procedure is more important in pediatric patients. The sedation, however, often involves risks and side effects, and their prediction and prevention should be sought in advance. Physicians should familiarize themselves to the relevant guidelines in order to make appropriate decisions and actions regarding the preparation of the sedation, patient monitoring during endoscopy, patient recovery, and hospital discharge. Furthermore, they have to understand the characteristics of the pediatric patients and different types of endoscopy. The purpose of this article is to discuss the details of sedation in pediatric endoscopy.

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Efficiency of propofol versus midazolam and fentanyl sedation at a pediatric teaching hospital: a prospective study

Cited by 38 publications

References 31 publications

Propofol versus Midazolam for Sedation during Esophagogastroduodenoscopy in Children

Propofol versus Midazolam for Sedation during Esophagogastroduodenoscopy in Children

Sedación, Seguridad y Utilidad de la Endoscopia Digestiva Alta en Pediatría

Sedation for Pediatric Endoscopy

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