Efficiency of <sup>123</sup>I-ioflupane SPECT as the marker of basal ganglia damage in acute methanol poisoning: 6-year prospective study

Kotikova, Katerina; Zogala, David; Ptáčník, Václav; Trnka, Jiří; Kupka, Karel; Vaněčková, Manuela; Seidl, Zdeněk; Diblik, Pavel; Heissigerová, Jarmila; Navrátil, Tomáš; Komarc, Martin; Zak, Ivan; Poláková, Kamila; Brožová, Hana; Zakharov, Sergey

doi:10.1080/15563650.2020.1802033

Cited by 3 publications

(2 citation statements)

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“…Disturbances in energy metabolism and neurotransmitter systems, such as depletion of striatal dopamine and immune responses, are among the disturbances reported for BG poisoning by Met and FA [51]. Thus, the effects of Met toxicity on BG are complex and multifactorial.…”

Section: Discussionmentioning

confidence: 99%

Toxicology and Metabolic Effects of Methanol and Formaldehyde on the Brain, a ReviewA rticle

Mansouri,

Rezaei-Tavirani,

Ahmadzadeh

et al. 2024

IJMTFM

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Background: Methanol is a toxic alcohol for the human body. The molecular biology of methanol metabolites affecting different organs, such as the brain, is under investigation. This systematic review aimed to consider methanol toxic molecular biology, based on the original articles obtained from data banks to figure out recent achievements. Methods: Scientific articles regarding the toxic effects and metabolites of methanol on the central nervous system (CNS) were collected from valid databases and classified based on their validity. Exclusion criteria were articles with duplicates, no available full text, review articles, case reports, and letters. Results: Current metabolic reactions were addressed in the development of CNS diseases, such as optic neuropathy, basal ganglia lesions, and Alzheimer’s disease. However, proteomic investigations introduced new metabolic changes, and serum proteins regarding blood coagulation, vitamin A metabolism, and immune responses were suggested for early detection of toxicity. Conclusion: Besides CNS disorders introduced for methanol toxicity, there is no exact proteomic serum marker to diagnose toxicity soon; however, the interleukin-1 beta system is suggested as a candidate, and more investigation is required to improve its competency.

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Section: Discussionmentioning

confidence: 99%

Toxicology and Metabolic Effects of Methanol and Formaldehyde on the Brain, a ReviewA rticle

Mansouri,

Rezaei-Tavirani,

Ahmadzadeh

et al. 2024

IJMTFM

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“…Methanol-induced brain basal ganglia damage, mostly bilateral necrosis of the putamen, and lesions in subcortical white matter are typical magnetic resonance findings associated with severe neurological sequelae (secondary parkinsonism) in survivors 10 , 11 .…”

Section: Introductionmentioning

confidence: 99%

Acute and chronic blood serum proteome changes in patients with methanol poisoning

Cejnar

Smirnova

Kučková

et al. 2022

Sci Rep

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Twenty-four blood serum samples from patients with acute methanol poisoning (M) from the mass methanol poisoning outbreak in the Czech Republic in 2012 were compared with 46 patient samples taken four years after poisoning (S) (overlap of 10 people with group M) and with a control group (C) of 24 samples of patients with a similar proportion of chronic alcohol abuse. When comparing any two groups, tens to hundreds of proteins with a significant change in concentration were identified. Fifteen proteins showed significant changes when compared between any two groups. The group with acute methanol poisoning showed significant changes in protein concentrations for at least 64 proteins compared to the other groups. Among the most important identified proteins closely related to intoxication are mainly those involved in blood coagulation, metabolism of vitamin A (increased retinol-binding protein), immune response (e.g., increased complement factor I, complement factors C3 and C5), and lipid transport (increased apolipoprotein A I, apolipoprotein A II, adiponectin). For blood coagulation, the most affected proteins with significant changes in the methanol poisoning group were von Willebrand factor, carboxypeptidase N, alpha-2-antiplasmin (all increased), inter-alpha-trypsin inhibitor heavy chain H4, kininogen-1, plasma serine protease inhibitor, plasminogen (all decreased). However, heparin administration used for the methanol poisoning group could have interfered with some of the changes in their concentrations. Data are available via ProteomeXchange with the identifier PXD035726.

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Höffding step and beyond: The impact of visual sensory impairment on cognitive performance in neuropsychological testing of survivors of acute methanol poisoning

Bukačová

Mana

Zakharov

et al. 2023

NRE

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BACKGROUND: Sensory deficits can result in limitations regarding how well neuropsychological test findings can be interpreted. Only a few studies have investigated the influence of vision alteration on neuropsychological tests. In 2012 the Czech Republic experienced mass methanol poisoning. Methanol metabolites cause histotoxic hypoxia to the optic nerve. OBJECTIVE: In the current study, the effect of the toxic damage on the parts of the visual pathway on visual and non-visual neuropsychological measures was investigated using electrophysiological methods (visual evoked potential (VEP) and optical coherence tomography (OCT) with retinal nerve fibre layer (RNFL) thickness measurement. METHODS: 53 individuals who experienced methanol poisoning participated in this research (76% men; ages 24 to 74 years, mean = 43.8±14.6 years; education 11.9±1.4 years). Each participant underwent comprehensive neurological, ophthalmological, and neuropsychological examinations. RESULTS: The results of mixed-effect models revealed significant small to a medium association between the Stroop test weak interference and Grooved Pegboard with the left eye global, nasal and temporal RNFL thickness. Also, medium associations between the Finger Tapping test and the Stroop test weak interference and OS temporal RNFL, right eye temporal RNFL, and the latency P1 of VEP in the left eye were significant. CONCLUSION: The results of this study found a small to medium association (r = .15– .33; p = .010– .046) between RNFL thickness and cognitive visual test performance. Careful interpretation is suggested regarding results obtained from visual tests of the executive or motor functioning with participants with RNFL decrease or other types of early visual processing damage.

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Efficiency of ¹²³I-ioflupane SPECT as the marker of basal ganglia damage in acute methanol poisoning: 6-year prospective study

Cited by 3 publications

References 46 publications

Toxicology and Metabolic Effects of Methanol and Formaldehyde on the Brain, a ReviewA rticle

Toxicology and Metabolic Effects of Methanol and Formaldehyde on the Brain, a ReviewA rticle

Acute and chronic blood serum proteome changes in patients with methanol poisoning

Höffding step and beyond: The impact of visual sensory impairment on cognitive performance in neuropsychological testing of survivors of acute methanol poisoning

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Efficiency of 123I-ioflupane SPECT as the marker of basal ganglia damage in acute methanol poisoning: 6-year prospective study

Cited by 3 publications

References 46 publications

Toxicology and Metabolic Effects of Methanol and Formaldehyde on the Brain, a ReviewA rticle

Toxicology and Metabolic Effects of Methanol and Formaldehyde on the Brain, a ReviewA rticle

Acute and chronic blood serum proteome changes in patients with methanol poisoning

Höffding step and beyond: The impact of visual sensory impairment on cognitive performance in neuropsychological testing of survivors of acute methanol poisoning

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Efficiency of ¹²³I-ioflupane SPECT as the marker of basal ganglia damage in acute methanol poisoning: 6-year prospective study