Efficiency of Transcranial Direct Current Stimulation (tDCS) in Anorexia Nervosa Treatment- Case Report

Rząd, Zuzanna; Szewczyk, P.; Róg, Joanna; Karakuła-Juchnowicz, Hanna

doi:10.2478/cpp-2022-0011

Cited by 3 publications

(16 citation statements)

References 22 publications

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“…A low-intensity direct current is used -up to 2000uA-2mA. Possible results confirming the effectiveness of this therapy could be an argument for introducing it to treatment in psychiatric wards or at home [35] Medium and large between-group differences in mood and quality of life and small between-group differences in BMI in the rTMS groups; faster rate of weight gain in the rTMS group compared with the control group at 18 months (BMI over 18.5 kg/m2: 46% vs. 9%). Electroconvulsive Therapy (ECT)…”

Section: Tdcs In Anorexia Nervosamentioning

confidence: 99%

Neuromodulation in the treatment of anorexia nervosa - a literature review

Metelska,

Permoda-Pachuta,

Karakuła-Juchnowicz

2024

Arch Psych Psych

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Introduction Anorexia nervosa (AN) is a disorder in which an unnaturally low body weight is deliberately maintained, with the coexistence of a distorted body image. The effectiveness of AN treatment so far is about 40%. For this reason, new methods of treatment are sought, which include brain neuromodulation techniques. Purpose The aim of this article was to determine the effectiveness of neuromodulation techniques in the treatment of AN. Materials and methods The literature on the use of neuromodulation techniques in patients with AN was reviewed via electronic databases: PubMed/MEDLINE, Google Scholar, ClinicalTrial.gov. The scope of the search was limited to 01/01/2008-03/01/2023. Articles in English, such as: randomized controlled trials, non-randomized controlled trials, case reports, were included. In order to verify the quality of the article, the six-point SANRA scale (Scale for the Assessment of Narrative Review Articles) was used. Results The results of the studies conducted so far are not homogeneous. The limitation of conclusions is primarily due to the small number and type of clinical trials conducted, involving small groups of subjects. The literature on the subject lacks systematic reviews and meta-analyses, which makes it impossible to reliably determine the effectiveness of therapy. Conclusions Based on Evidence-Based Medicine and the level of credibility of the available data, there is insufficient evidence to recommend neuromodulation techniques for the standard treatment of AN. Further randomized, double-blind clinical trials are needed to assess the effectiveness of this form of treatment. However, the existing data are promising.

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Section: Tdcs In Anorexia Nervosamentioning

confidence: 99%

Neuromodulation in the treatment of anorexia nervosa - a literature review

Metelska,

Permoda-Pachuta,

Karakuła-Juchnowicz

2024

Arch Psych Psych

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“…Rzad et al [71] presented a case report involving the application of tDCS on an 18-year-old female participant. The study aimed to assess several aspects, including anthropometric measures, biological factors, and psychological aspects.…”

Section: Summary Of Included Studiesmentioning

confidence: 99%

“…All the studies included in this research employed anodal stimulation on the left dorsolateral prefrontal cortex (DLPFC). Four of the studies [68][69][70][71] followed the international 10-20 system to position the electrodes accurately. This method involves measuring the participant's head to identify specific regions of interest, and based on this, the anodal electrode was placed at F3.…”

Section: Technical Aspects Of Tdcs In An and Safetymentioning

confidence: 99%

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The Effect of Transcranial Direct Current Stimulation (tDCS) on Anorexia Nervosa: A Narrative Review

Chmiel,

Gladka,

Leszek

2023

Nutrients

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(1) Introduction: Anorexia nervosa (AN) is a severe, debilitating disease with high incidence and high mortality. The methods of treatment used so far are moderately effective. Evidence from neuroimaging studies helps to design modern methods of therapy. One of them is transcranial direct current stimulation (tDCS), a non-invasive brain neuromodulation technique. (2) Methods: The purpose of this narrative review is to bring together all studies investigating the use of tDCS in the treatment of AN and to evaluate its effect and efficiency. Searches were conducted in the Pubmed/Medline, Research Gate, and Cochrane databases. (3) Results: The literature search resulted in five articles. These studies provide preliminary evidence that tDCS has the potential to alter eating behaviour, body weight, and food intake. Additionally, tDCS reduced symptoms of depression. Throughout all trials, stimulation targeted the left dorsolateral prefrontal cortex (DLPFC). Although the number of studies included is limited, attempts were made to elucidate the potential mechanisms underlying tDCS action in individuals with AN. Recommendations for future tDCS research in AN were issued. (4) Conclusions: The included studies have shown that tDCS stimulation of the left DLPFC has a positive effect on AN clinical symptoms and may improve them, as measured by various assessment measures. It is important to conduct more in-depth research on the potential benefits of using tDCS for treating AN. This should entail well-designed studies incorporating advanced neuroimaging techniques, such as fMRI. The aim is to gain a better understanding of how tDCS works in AN.

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“…Although the results did not show major improvements in AN psychopathology or weight recovery compared with sham tDCS, active tDCS reduced the need for excessive control over food intake and improved body image. In addition, three small open-label studies [ 16 , 45 , 71 ] and one case report [ 67 ] have examined tDCS efficacy of left DLPFC anodal stimulation in people with AN. Although these studies have varied in terms of treatment protocols (e.g., treatment administered three times a week over 6 weeks or once and twice per day over ten days), all studies suggested benefits for core eating disorder symptoms with the pilot studies showing maintained benefits at 1 month follow up post end acute treatment.…”

Section: Introductionmentioning

confidence: 99%

Randomised controlled trial of neurostimulation for symptoms of anorexia nervosa (TRENA study): study protocol

Harvey,

Madden,

Rodgers

et al. 2023

J Eat Disord

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Background Anorexia nervosa (AN) has amongst the highest mortality rates and the highest treatment costs of any psychiatric disorder. Recently, interest in non-invasive brain stimulation as a novel treatment for AN has grown. These include repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS). Methods This double-blind, randomised sham-controlled trial will compare the relative acceptability and efficacy of tDCS and rTMS in people with AN. 70 participants will be randomised to active or sham tDCS, or active or sham rTMS treatment (2:1:2:1 ratio) over an 8-week treatment period. Participants will receive treatment as usual across the study duration. The primary outcomes are change on the Eating Disorder Examination Questionnaire and treatment acceptability. Secondary outcomes will include change in weight, cognition, mood, interpersonal functioning, and quality of life. Following the 8-week assessment, all participants will have the option of receiving an additional 12 weeks of at-home tDCS. A follow-up assessment will be conducted at 20 weeks post treatment. Discussion Research into non-invasive brain stimulation as treatments for AN has potential to improve clinical outcomes for patients by comparing the relative efficacy and acceptability of both treatment modalities in the inpatient and at-home setting (i.e., for at-home tDCS) results from this study will provide important information for informing future larger clinical trials of these treatments for AN. Trial registration ClinicalTrials.gov Identifier: NCT05788042.

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Efficiency of Transcranial Direct Current Stimulation (tDCS) in Anorexia Nervosa Treatment- Case Report

Cited by 3 publications

References 22 publications

Neuromodulation in the treatment of anorexia nervosa - a literature review

Neuromodulation in the treatment of anorexia nervosa - a literature review

The Effect of Transcranial Direct Current Stimulation (tDCS) on Anorexia Nervosa: A Narrative Review

Randomised controlled trial of neurostimulation for symptoms of anorexia nervosa (TRENA study): study protocol

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