Efficient and eco-friendly detection of gabapentin using nitrogen-doped carbon quantum dots: an analytical and green chemistry approach

Almalki, Atiah H.; Abdelazim, Ahmed H.; Alosaimi, Manal E.; Abduljabbar, Maram H.; Alnemari, Reem M.; Bamaga, Ahmed K.; Serag, Ahmed

doi:10.1039/d3ra07365c

RSC Adv.

2024

DOI: 10.1039/d3ra07365c

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Efficient and eco-friendly detection of gabapentin using nitrogen-doped carbon quantum dots: an analytical and green chemistry approach

Atiah H. Almalki,

Ahmed H. Abdelazim,

Manal E. Alosaimi

et al.

Abstract: An environmentally friendly N-CQDs-based fluorescence sensor for gabapentin detection is developed, with optimal detection conditions and high selectivity, accuracy, and precision in real sample analysis.

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Cited by 4 publications

References 37 publications

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Functionalized Graphene Quantum Dots as an Eco‐Friendly Fluorescent Probe for Galantamine Analysis: Greenness Evaluation With Application to Pharmacokinetics Monitoring

Alosaimi,

Almalki,

Abduljabbar

et al. 2024

Luminescence

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In this study, the use of functionalized graphene quantum dots (GQDs) as a fluorescent probe has been investigated for the quantitative determination of galantamine, a choline esterase inhibitor used for the treatment of Alzheimer's disease. The GQDs exhibit a significant quenching in their fluorescence intensity upon interaction with galantamine allowing for sensitive and selective detection of the drug. This quenching process follows a dynamic pattern with a linear relationship between fluorescence intensity and the concentration of galantamine. Several factors affecting the quenching process were investigated and optimized, including the concentration of GQDs, the pH of the solution, and the incubation time. The proposed probe exhibited excellent analytical performance with a linear range of 10–500 ng/mL, a limit of detection of 15 ng/mL, accuracy of 100.78 ± 0.698%, and intraday and interday precision of 0.742 and 1.369%, respectively. Furthermore, the GQDs‐based sensor exhibited good selectivity towards galantamine in the presence of potentially interfering substances. Another advantage of the GQDs‐based sensor is its greenness evaluation, as it offers a more environmentally friendly alternative compared to traditional methods. In addition, the GQDs‐based sensor was successfully applied to analyze galantamine in pharmaceutical samples and in vivo samples, demonstrating its potential for pharmacokinetics monitoring.

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Functionalized Graphene Quantum Dots as an Eco‐Friendly Fluorescent Probe for Galantamine Analysis: Greenness Evaluation With Application to Pharmacokinetics Monitoring

Alosaimi,

Almalki,

Abduljabbar

et al. 2024

Luminescence

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show abstract

A Box-Behnken response surface methodology for optimizing fluorescent detection of cenobamate using graphene quantum dots: Environmental impact assessment and pharmacokinetic applications

Almalki,

Abduljabbar,

Alnemari

et al. 2024

Microchemical Journal

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Eco-friendly graphene quantum dots as a novel spectrofluorimetric probe for lamivudine quantification with evaluation of its greenness and blueness profiles

Alqahtani,

Serag

2024

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Efficient and eco-friendly detection of gabapentin using nitrogen-doped carbon quantum dots: an analytical and green chemistry approach

Abstract: An environmentally friendly N-CQDs-based fluorescence sensor for gabapentin detection is developed, with optimal detection conditions and high selectivity, accuracy, and precision in real sample analysis.

Cited by 4 publications

References 37 publications

Functionalized Graphene Quantum Dots as an Eco‐Friendly Fluorescent Probe for Galantamine Analysis: Greenness Evaluation With Application to Pharmacokinetics Monitoring

Functionalized Graphene Quantum Dots as an Eco‐Friendly Fluorescent Probe for Galantamine Analysis: Greenness Evaluation With Application to Pharmacokinetics Monitoring

A Box-Behnken response surface methodology for optimizing fluorescent detection of cenobamate using graphene quantum dots: Environmental impact assessment and pharmacokinetic applications

Eco-friendly graphene quantum dots as a novel spectrofluorimetric probe for lamivudine quantification with evaluation of its greenness and blueness profiles

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