Efficient and High-Yielding Protocol for the Synthesis of Nitriles from Aldehydes

Triphenylphosphine (PPh3) Catalyzed Erlenmeyer Reaction for Azlactones under Solvent‐free Conditions

“…The most well‐known route for the synthesis of azlactones, involves the direct condensation of aromatic aldehydes and hippuric acid with a stoichiometric amount of fused sodium acetate as a base in the presence of acetic anhydride as the dehydrating agent, which is known as Erlenmeyer–Plochl reaction . Further number of methods have been used for the synthesis of oxazolones such as Nano‐MgO , Bi(OTf) 3 , Pb(OAc) 2 , I 2 , K 3 PO 4 , Al 2 O 3 –H 3 BO 3 , Bi(OAc) 3 , [C 6 (MIm) 2 ] 2 W 10 O 32 , 2H 2 O , Montmorillonite K‐10 , and alumina , instead of sodium acetate. Microwave‐assisted reactions have also been employed successfully in the synthesis of the oxazolones .…”