Efficient and Selective Construction of Pyrrolo[3,2-d]pyrimidine Derivatives

Abstract

An efficient and selective method for the synthesis of ethyl 2-amino/aryloxy-3-aryl-4-oxo-5-phenyl-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidine-7-carboxylate derivatives has been developed. The main process involved the reaction of diethyl 1-phenyl-3-((triphenylphosphoranylidene)amino)-1H-pyrrole-2,4-dicarboxylate and aromatic isocyanates, followed by addition of amines/phenols in the presence of catalytic amount of sodium ethoxide or solid potassium carbonate.

Synthesis of Pyrrolo[3, 4-d]Pyrimidine Thiono Derivatives via Aza Wittig Reaction

“…Carbonyl groups of aldehydes, ketones, acid halides, and heterocumulenes are generally reactive (Daboun et al, 1983). Recently we have been interested in the synthesis of new pyrrolo [3,4-d] pyrimidine derivatives via aza-Wittig reaction by pyrimidines nuclei with phenylisocyanate (He et al, 2013(He et al, , 2014. Pyrimidine derivatives play an important role in several biological and pharmacological active substances such as antibacterial and antitumor agents as well as agrochemical and veterinary products (Wright et al, 1977;Taylor et al, 1992;Traxler et al, 1997;Vicentini et al, 1989;Molina et al, 1994).…”