Efficient and straightforward click synthesis of structurally related dendritic triazoles

Abstract

Structurally related triazolic dendrimers were efficiently synthesized applying CuAAC reaction.

CoFe2O4/Cu(OH)2 magnetic nanocomposite: an efficient and reusable heterogeneous catalyst for one-pot synthesis of β-hydroxy-1,4-disubstituted-1,2,3-triazoles from epoxides

“…13 The Huisgen 1,3-dipolar cycloaddition of alkynes and organic azides has been developed as the principal method for synthesis of 1,2,3-triazoles. [14][15][16][17][18][19][20][21][22] Recently, multicomponent onepot synthesis of b-hydroxy-1,2,3-triazoles has been carried out through in situ click reaction of azides, alkynes and epoxides in the presence of heterogeneous copper catalysts such as carbon supported copper nanoparticles, 23,24 porphyrinatocopper nanoparticles, 25 CuSO 4 $5H 2 O/sodium ascorbate, 26 copper(I)-zeolite, 27 Cu[N 2 ,N 6 -bis(2-hydroxyphenyl)pyridine-2,6-dicarboxamidate]/ ascorbic acid, 28 copper ferrite nanoparticles, 29 copper(I)@phosphorated SiO 2 , 30 Cu(OAc) 2 $H 2 O, 31 (Cu/Cu 2 O) nanoparticles, 32 Cu(II)-azide complexes, 33 Cu(II)-DA@nano AlPO 4 , 34 1,4-dihydroxyanthraquinone-copper(II) nanoparticles immobilized on silica gel, 35 4 0 -phenyl-2,2 0 :6 0 ,2 00 -terpyridine copper(II) complex immobilized on activated multiwalled carbon nanotubes, 36 CuI 37 and NiFe 2 O 4 -glutamate-Cu. 38 Ramachary-Bressy-Wang cycloaddition of enolate intermediates and organic azides is the other basic method for one-pot preparation of 1,4-disubstituted-1,2,3-triazoles.…”

Base-Promoted SNAr Reactions of Fluoro- and Chloroarenes as a Route to N-Aryl Indoles and Carbazoles

“…4-(Carbazol-9-yl)benzamide ( 5i ) [52]: White solid (168.9 mg, 59%); 1 H-NMR (400 MHz, CDCl 3 ) δ 8.15 (d, J = 7.7 Hz, 2H), 8.07 (d, J = 8.3 Hz, 2H), 7.69 (d, J = 8.1 Hz, 2H), 7.45–7.38 (m, 4H), 7.32 (t, J = 7.5 Hz, 2H), 6.14 (s br , 2H); 13 C-NMR (100 MHz, CDCl 3 ) δ 168.6, 141.3, 140.4, 131.9, 129.3, 126.8, 126.3, 123.8, 120.6, 120.5, 109.8; GC-MS m / z : 286 (M + ).…”

Cellulose‐Supported CuI‐Nanoparticles‐Mediated Green Synthesis of Trifluoromethylbenzoate‐Linked Triazoles for Pharmacological & DFT study

“…In this method benzyl azides prepared in‐situ and thus not isolated and characterized. However, aryl azides prepared from commercially available aniline derivatives by reaction with sodium nitrite (NaNO 2 ) in acidic condition by classical diazotization‐azidation reaction . The alkyne derivative ( 2 ) was prepared from commercially available 4‐trifluoromethyl‐benzoic acid reaction with propargyl bromide and K 2 CO 3 using Dimethylformamide (DMF) as a solvent as per the reported procedure .…”

“…However, aryl azides prepared from commercially available aniline derivatives by reaction with sodium nitrite (NaNO 2 ) in acidic condition by classical diazotizationazidation reaction. [27] The alkyne derivative (2) was prepared from commercially available 4-trifluoromethyl-benzoic acid reaction with propargyl bromide and K 2 CO 3 using Dimethylformamide (DMF) as a solvent as per the reported procedure. [14b] The prepared alkyne was successfully characterized by IR, 1 H-NMR, 13 C-NMR and HRMS spectroscopy.…”