Efficient and targeted drug/siRNA co-delivery mediated by reversibly crosslinked polymersomes toward anti-inflammatory treatment of ulcerative colitis (UC)

Twenty-five years of polymersomes: lost in translation?

“…Another polymersome system with a disulfide-bond crosslinked membrane was recently proposed for the treatment of ulcerative colitis. 126 The polymersomes were composed of PEO-bpoly(trimethylene carbonate-co-dithiolane trimethylene carbonate)b-poly(ethyleneimine) and PEO-b-poly(trimethylene carbonateco-dithiolane trimethylene carbonate) modified with a macrophagetargeting peptide. 126 The polymers self-assembled into asymmetric vesicles with of the cationic poly(ethyleneimine) facing the aqueous core, leading to an almost neutral surface charge.…”

“…126 The polymersomes were composed of PEO-bpoly(trimethylene carbonate-co-dithiolane trimethylene carbonate)b-poly(ethyleneimine) and PEO-b-poly(trimethylene carbonateco-dithiolane trimethylene carbonate) modified with a macrophagetargeting peptide. 126 The polymers self-assembled into asymmetric vesicles with of the cationic poly(ethyleneimine) facing the aqueous core, leading to an almost neutral surface charge. 126 The polymersomes were loaded with a silencing ribonucleic acid against tumor necrosis factor-alpha and dexamethasone sodium phosphate.…”

“…126 The polymers self-assembled into asymmetric vesicles with of the cationic poly(ethyleneimine) facing the aqueous core, leading to an almost neutral surface charge. 126 The polymersomes were loaded with a silencing ribonucleic acid against tumor necrosis factor-alpha and dexamethasone sodium phosphate. 126 In a biodistribution study, the polymersomes with the macrophagetargeting peptide homed to the colon to a significantly higher extent than the peptide-free vesicle control after intravenous application.…”

“…126 The polymersomes were loaded with a silencing ribonucleic acid against tumor necrosis factor-alpha and dexamethasone sodium phosphate. 126 In a biodistribution study, the polymersomes with the macrophagetargeting peptide homed to the colon to a significantly higher extent than the peptide-free vesicle control after intravenous application. 126 In an ulcerative colitis mouse model, the doubleloaded polymersomes led to a significant downregulation of tumor necrosis factor-alpha and attenuated several markers of ulcerative colitis disease activity.…”

The rise of bio-inspired polymer compartments responding to pathology-related signals

“…Polymersomes can be rendered more stable by cross-linking approaches, but only if the resulting assemblies retain a very low cytotoxicity. 53,55,110,115,218 The structure of PICsomes was stabilized in different smart ways that should be adopted for future PICsome-based sensors. The contributions of the molecular backbone play a very important role in enhancing the stability of PICsomes and in expanding the preparation conditions.…”