Efficient anti-tumor effect of photodynamic treatment with polymeric nanoparticles composed of polyethylene glycol and polylactic acid block copolymer encapsulating hydrophobic porphyrin derivative

Ogawara, Ken Ichi; Shiraishi, Taro; Araki, Tomoya; Watanabe, Takeru; Ono, Tsutomu; Higaki, Kazutaka

doi:10.1016/j.ejps.2015.11.016

Cited by 19 publications

(11 citation statements)

References 39 publications

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“…Special delivery forms such as liposomes (Reshetov et al 2013), polymeric nanoparticle (Ogawara et al 2016) and dendrimers (Bastien et al 2015) were extensively studied and showed important progress in drug delivery and PDT. Among the investigated drug delivery systems, cyclodextrins are promising PSs carriers (Kryjewski et al 2015;Mazzaglia 2011).…”

Section: Introductionmentioning

confidence: 99%

Inclusion complexation with β-cyclodextrin derivatives alters photodynamic activity and biodistribution of meta-tetra(hydroxyphenyl)chlorin

Yankovsky

Bastien

Yakavets

et al. 2016

European Journal of Pharmaceutical Sciences

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Section: Introductionmentioning

confidence: 99%

Inclusion complexation with β-cyclodextrin derivatives alters photodynamic activity and biodistribution of meta-tetra(hydroxyphenyl)chlorin

Yankovsky

Bastien

Yakavets

et al. 2016

European Journal of Pharmaceutical Sciences

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“…The challenge may be achieved by designing drug delivery systems for photosensitizers to overcome above-mentioned disadvantages. Many different nanoparticles have been proposed as PS delivery systems, for example, liposomes, , polymeric nanoparticles, or silica nanoparticles . Among many types of nanosystems, dendrimers have been proven to be promising platforms for drug delivery, especially because of their regular, hyperbranched architecture, which specifically enables several different ways to attach drug molecules to a carrier. − PS molecules can be attached either to the internal or surface groups.…”

Section: Introductionmentioning

confidence: 99%

Cationic Phosphorus Dendrimer Enhances Photodynamic Activity of Rose Bengal against Basal Cell Carcinoma Cell Lines

et al. 2017

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In the last couple of decades, photodynamic therapy emerged as a useful tool in the treatment of basal cell carcinoma. However, it still meets limitations due to unfavorable properties of photosensitizers such as poor solubility or lack of selectivity. Dendrimers, polymers widely studied in biomedical field, may play a role as photosensitizer carriers and improve the efficacy of photodynamic treatment. Here, we describe the evaluation of an electrostatic complex of cationic phosphorus dendrimer and rose bengal in such aspects as singlet oxygen production, cellular uptake, and phototoxicity against three basal cell carcinoma cell lines. Rose bengal-cationic dendrimer complex in molar ratio 5:1 was compared to free rose bengal. Obtained results showed that the singlet oxygen production in aqueous medium was significantly higher for the complex than for free rose bengal. The cellular uptake of the complex was 2-7-fold higher compared to a free photosensitizer. Importantly, rose bengal, rose bengal-dendrimer complex, and dendrimer itself showed no dark toxicity against all three cell lines. Moreover, we observed that phototoxicity of the complex was remarkably enhanced presumably due to high cellular uptake. On the basis of the obtained results, we conclude that rose bengal-cationic dendrimer complex has a potential in photodynamic treatment of basal cell carcinoma.

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“…The PN-Por showed significant phototoxicity in vitro and effective antitumor effect in C26 tumor-bearing mice in vivo . All results exhibited the potency of PN-Por for PDT-based cancer treatments (Ogawara et al, 2016 ). In another study, in order to increase the solubility and delivery efficiency of PpIX, Ding et al prepared PpIX loaded polymeric micelles using non-covalent encapsulation and covalent conjugation methods.…”

Section: Photodynamic Therapy Componentsmentioning

confidence: 79%

Poly(Ethylene Glycol)–Polylactide Micelles for Cancer Therapy

et al. 2018

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For the treatment of malignancy, many therapeutic agents, including small molecules, photosensitizers, immunomodulators, proteins and genes, and so forth, have been loaded into nanocarriers for controllable cancer therapy. Among these nanocarriers, polymeric micelles have been considered as one of the most promising nanocarriers, some of which have already been applied in different stages of clinical trials. The successful advantages of polymeric micelles from bench to bedside are due to their special core/shell structures, which can carry specific drugs in certain disease conditions. Particularly, poly(ethylene glycol)–polylactide (PEG–PLA) micelles have been considered as one of the most promising platforms for drug delivery. The PEG shell effectively prevents the adsorption of proteins and phagocytes, thereby evidently extending the blood circulation period. Meanwhile, the hydrophobic PLA core can effectively encapsulate many therapeutic agents. This review summarizes recent advances in PEG–PLA micelles for the treatment of malignancy. In addition, future perspectives for the development of PEG–PLA micelles as drug delivery systems are also presented.

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Efficient anti-tumor effect of photodynamic treatment with polymeric nanoparticles composed of polyethylene glycol and polylactic acid block copolymer encapsulating hydrophobic porphyrin derivative

Cited by 19 publications

References 39 publications

Inclusion complexation with β-cyclodextrin derivatives alters photodynamic activity and biodistribution of meta-tetra(hydroxyphenyl)chlorin

Inclusion complexation with β-cyclodextrin derivatives alters photodynamic activity and biodistribution of meta-tetra(hydroxyphenyl)chlorin

Cationic Phosphorus Dendrimer Enhances Photodynamic Activity of Rose Bengal against Basal Cell Carcinoma Cell Lines

Poly(Ethylene Glycol)–Polylactide Micelles for Cancer Therapy

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