Efficient antiglioblastoma therapy in mice through doxorubicin-loaded nanomicelles modified using a novel brain-targeted RVG-15 peptide

Han, Mingfeng; Xing, Haoyue; Chen, Liqing; Cui, Minhu; Zhang, Yingying; Li, Qi; Jin, Mingji; Yang, Yang; Gao, Chunsheng; Gao, Zhonggao; Xing, Xue-zhong; Huang, Wei

doi:10.1080/1061186x.2021.1912053

Cited by 15 publications

(7 citation statements)

References 23 publications

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“…When the GLUT1 scF-modified micelles were compared with the non-modified micelles, the nuclear localization of DOX increased threefold. 121 Other types of polymeric micelles loaded with DOX are DOX-RVG-15-PMs (composed of RVG-29, a 29-amino-acid polypeptide derived from the rabies virus glycoprotein (RVG), and PEG2000-DSPE), 122 and MeO-PEG-DOX8 and CD (choline derivative)-PEG-DOX8, successfully caused DOX accumulation in the GBM tumor site. 123 Wei et al designed low-density lipoprotein receptor (LDLR)-specific micelles to improve the BBB penetration of sorafenib.…”

Section: Biomaterials For Gbm Drug Deliverymentioning

confidence: 99%

Advanced biomaterials for human glioblastoma multiforme (GBM) drug delivery

et al. 2023

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Section: Biomaterials For Gbm Drug Deliverymentioning

confidence: 99%

Advanced biomaterials for human glioblastoma multiforme (GBM) drug delivery

et al. 2023

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“…Starting from a viral glycoprotein, a derivative peptide of 15 amino acids called RVG15 was recently demonstrated to be a novel and efficient targeting peptide for BBB crossing, since it is able to bind the nicotinic acetylcholine receptor [52]. This peptide was conjugated onto the surface of soybean phosphatidylcholine, cholesterol, DSPE-PEG liposomes loaded with cholesterol-conjugated paclitaxel, providing BBB permeability and selectivity toward GBM cells [53].…”

Section: Dual Targeting Of the Bbb And Gbm Cellsmentioning

confidence: 99%

Recent Advances on Surface-Modified GBM Targeted Nanoparticles: Targeting Strategies and Surface Characterization

Rodà

Caraffi

Picciolini

et al. 2023

IJMS

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Glioblastoma multiforme (GBM) is the most common malignant brain tumor, associated with low long-term survival. Nanoparticles (NPs) developed against GBM are a promising strategy to improve current therapies, by enhancing the brain delivery of active molecules and reducing off-target effects. In particular, NPs hold high potential for the targeted delivery of chemotherapeutics both across the blood–brain barrier (BBB) and specifically to GBM cell receptors, pathways, or the tumor microenvironment (TME). In this review, the most recent strategies to deliver drugs to GBM are explored. The main focus is on how surface functionalizations are essential for BBB crossing and for tumor specific targeting. We give a critical analysis of the various ligand-based approaches that have been used to target specific cancer cell receptors and the TME, or to interfere with the signaling pathways of GBM. Despite the increasing application of NPs in the clinical setting, new methods for ligand and surface characterization are needed to optimize the synthesis, as well as to predict their in vivo behavior. An expert opinion is given on the future of this research and what is still missing to create and characterize a functional NP system for improved GBM targeting.

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“…The drug-loaded exosomes were able to scavenge α-synuclein aggregates and reduce cytotoxicity in PD neurons [ 121 ]. Han et al [ 122 ] synthesized RVG-15-PEG-DSPE and inserted it onto the surface of exosomes containing doxorubicin to achieve the treatment of glioblastoma. In addition to RVG, other types of brain-targeting small molecules can also be engineered by chemical ligations.…”

Section: Engineering Exosomes Enhance the Cns Targeting And Therapeut...mentioning

confidence: 99%

Exosomes as CNS Drug Delivery Tools and Their Applications

et al. 2022

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Central nervous system (CNS) diseases threaten the health of people all over the world. However, due to the structural and functional particularities of the brain and spinal cord, CNS-targeted drug development is rather challenging. Exosomes are small cellular vesicles with lipid bilayers that can be secreted by almost all cells and play important roles in intercellular communication. The advantages of low immunogenicity, the ability to cross the blood-brain barrier, and the flexibility of drug encapsulation make them stand out among CNS drug delivery tools. Herein, we reviewed the research on exosomes in CNS drug delivery over the past decade and outlined the impact of the drug loading mode, administration route, and engineered modification on CNS targeting. Finally, we highlighted the problems and prospects of exosomes as CNS drug delivery tools.

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Efficient antiglioblastoma therapy in mice through doxorubicin-loaded nanomicelles modified using a novel brain-targeted RVG-15 peptide

Cited by 15 publications

References 23 publications

Advanced biomaterials for human glioblastoma multiforme (GBM) drug delivery

Advanced biomaterials for human glioblastoma multiforme (GBM) drug delivery

Recent Advances on Surface-Modified GBM Targeted Nanoparticles: Targeting Strategies and Surface Characterization

Exosomes as CNS Drug Delivery Tools and Their Applications

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