Efficient Approach for Simultaneous Estimation of Multiple Health-Promoting Effects of Foods

Abstract

The investigation of new food constituents for purposes of disease prevention or health promotion is an area of increasing interest in food science. This paper proposes a new system that allows for simultaneous estimation of the multiple health-promoting effects of food constituents using informatics. The model utilizes expression data of intracellular marker proteins as descriptors that reply to stimulation of a constituent. To estimate three health-promoting effects, namely, cancer cell growth suppression activity, antiviral activity, and antioxidant stress activity, each model was constructed using expression data of marker proteins as input data and health-promoting effects as the output value. When prediction performances of three types of mathematical models constructed by simple, multiple regressions, or artificial neural network (ANN), were compared, the most adequate model was the one constructed using an ANN. There were no statistically significant differences between the actual data and estimated values calculated by the ANN models. This system was able to simultaneously estimate health-promoting effects with reasonable precision from the same expression data of marker proteins. This novel system should prove to be an interesting platform for evaluation of the health-promoting effects of food.

Oligomeric proanthocyanidins from rabbiteye blueberry leaves inhibits the proliferation of human T-cell lymphotropic virus type 1-associated cell lines via apoptosis and cell cycle arrest

“…Analysis of the chemical constituents by Matsuo et al has revealed that the most abundant polyphenols in rabbiteye BBL are oligomeric proanthocyanidins (Matsuo, et al, 2010). Since they can suppress hepatitis C virus replication (Nagahama, et al, 2011;Takeshita, et al, 2009), BBL have recently come to be used as a tea also in both North America and Japan. Recent studies show that the proanthocyanidins from rabbiteye BBL exert not only suppressive effect on hepatitis C virus replication but also some health-promoting effects in vitro or in vivo (Inoue, et al, 2011;Nagahama, et al, 2011;Takami, et al, 2010;Takeshita, et al, 2009).…”

“…Since they can suppress hepatitis C virus replication (Nagahama, et al, 2011;Takeshita, et al, 2009), BBL have recently come to be used as a tea also in both North America and Japan. Recent studies show that the proanthocyanidins from rabbiteye BBL exert not only suppressive effect on hepatitis C virus replication but also some health-promoting effects in vitro or in vivo (Inoue, et al, 2011;Nagahama, et al, 2011;Takami, et al, 2010;Takeshita, et al, 2009). Noteworthy, orally administered proanthocyanidins fraction from rabbiteye BBL, which is separated by a similar method as our study, enhances lipolysis in the liver, resulting in the fraction exerts hypolipidemic effect on obese Otsuka Long-Evans Tokushima Fatty rats (Inoue, et al, 2011).…”