Efficient catalyst-free tricomponent synthesis of new spiro[cyclohexane-1,4′-pyrazolo[3,4-e][1, 4]thiazepin]-7′(6′H)-ones

Abstract

ExperimentalS2 General procedure for synthesis of 1-aryl-3-methyl-5-aminopyrazoles (3a-e). S2 1 H NMR spectrum of compound 3a S4 13 C NMR spectrum of compound 3a S5 1 H NMR spectrum of compound 3b S5 13 C NMR spectrum of compound 3b S6 1 H NMR spectrum of compound 3c S6 13 C NMR spectrum of compound 3c S7 1 H NMR spectrum of compound 3d S7 13 C NMR spectrum of compound 3d S8 1 H NMR spectrum of compound 3e S8 13 C NMR spectrum of compound 3e S9 General procedure for synthesis of synthesis of spiro[cyclohexane-1,4´-pyrazolo[3,4e][1,4]thiazepin]-7(6´H)-ones (4a-d). S9 1 H NMR spectrum of compound 4a S12 13 C NMR spectrum (Includes DEPT-135) of compound 4a S12 1 H NMR spectrum of compound 4b S13 13 C NMR spectrum (Includes DEPT-135) of compound 4b S13 1 H NMR spectrum of compound 4c S14 13 C NMR spectrum (Includes DEPT-135) of compound 4c S14 1 H NMR spectrum of compound 4d S15 13

Organocatalytic Chemoselective C4‐Benzylation of 5‐Aminopyrazoles

“…The authors have cited additional references within the Supporting Information (Ref. [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40]).…”