Efficient catalytic method for the synthesis of N-aryl-substituted 1,5,3-dithiazamacroheterocycles

Stability in biosensors derived from domain map analysis of bibliometric data

“…Cluster #10 “Poly(o-phenylenediamine)” was formed by 130 publications, of which the ten most important are publications ( Ahammad et al, 2011 ; Devi et al, 2013 ; Zhang et al, 2014 ; Dervisevic et al, 2015a ; Baytak et al, 2015 ; Dervisevic et al, 2015b ; Chen et al, 2015 ; Tan et al, 2015 ; Wang et al, 2015 ), while clusters #11 “Lectins” and #12 “Optimization” were formed by 65 and 163 publications, respectively. The most important for cluster #11 are Bai and Shiu (2014) , Gholivand et al (2014) , Oliveira et al (2014) , Ribeiro et al (2014) , Ghanbari et al (2019) , Bravo et al (2022) , Jalalvand (2022) , Tvorynska et al (2022) , Zalpour et al (2022) , Ramesh et al (2023) , while for cluster 12 ( Hsu et al, 2009 ; Kong et al, 2009 ; Liu et al, 2011a ; Liu et al, 2011a ; Liu et al, 2011b ; Pasahan et al, 2011 ; Yang HC et al, 2011 ; Yang WY et al, 2011 ; Makhmudiyarova et al, 2015 ; Rakhi et al, 2016 ) with information on operational stability as well as sensitivity, conductivity, detection limits, response speed, detection range, calculation of the Michaelis-Menten constant, response gain.…”

Samarium(III) nitrate-catalyzed one-pot synthesis of 42-membered N,S,O-containing cyclophanes

“…N,N-bis(methoxymethyl)-N-arylamines 1a-g (CH 2 Cl 2 for 1 a,f,g; EtOAc + CH 2 Cl 2 for 1 b,c; EtOAc + EtOH for 1 d; EtOAc for 1e). 46 The reaction mixture was stirred ~ 20 о С for 7 h and concentrated, and the residue was purified by column chromatography on SiO 2 to isolate pure heterocyclic product . N-(m-Chlorophenyl)-1,15,29-trioxa-6,10,20,24,34,38-hexathia-8,22,36-triaza[1.5.1 N-(m-Methylphenyl)-1,15,29-trioxa-6,10,20,24,34,38-hexathia-8,22,36-triaza[1 N-(о-Methoxyphenyl)-1,15,29-trioxa-6,10,20,24,34,38-hexathia-8,22,36-triaza[1.5.1 N-(о-Chlorophenyl)-1,15,29-trioxa-6,10,20,24,34,38-hexathia-8,22,36-triaza[1.5.1 N-(о-Bromophenyl)-1,15,29-trioxa-6,10,20,24,34,38-hexathia-8,22,36-triaza[1.5.1 …”

“…were chosen as the starting compounds because, when introduced into catalytic heterocyclization with α,ω-alkanethiols, they afford 1,5,3-dithiazacycloalkanes according to a [1+1]-cyclocondensation route with high selectivity 40,46 while conformationally rigid 4,4′-dimercaptodiphenyl oxide favours the formation of macroheterocycles upon [3+3]-cyclocondensation, for example, with СН 2 О and primary hydroxylamines. 6H 2 O (20 °С, 7 h), macroheterocycle 3а is formed in 70% yield according to Scheme 1.…”

“…This catalyst was chosen for its high activity and selectivity of action in the previously studied heterocyclizations. 46 Without a catalyst, macroheterocycle 3a is not formed. with m/z 1156.225 was observed in the MALDI-TOF mass spectrum (HCCA matrix), confirming the structure of paracyclophane 3a.…”

Catalyzed ring transformation of cyclic N-aryl-azadiperoxides with participation of α,ω-dithiols

“…Under conditions including 5 mol% of Co(OAc) 2 , 20 °C, MeOH, and 20 h, 10-phenyl-7,8,12,13-tetraoxa-10-azaspiro[5.7]tridecane 1 was allowed to react with propane-1,3- 3, butane-1,4- 4, pentane-1,5- 5, and hexane-1,6-dithiols 6, which furnished the corresponding 3-phenyl-1,5,3-dithiaazacycloalkanes 16 9–12 in 83–89% yields ( Table 1 ). The ring transformation reaction of azadiperoxide 1 with 3,6-dioxa-1,8-octanedithiol 7 (monooxa derivative is shown in the scheme) under the conditions described above resulted in the synthesis of 6-phenyl-1,11-dioxa-4,8-dithia-6-azacyclotridecane 16 12 in 91% yield ( Scheme 1 ).…”