Efficient catalytic oxidation of primary benzylic C H bonds with molecular oxygen catalyzed by cobalt porphyrins and N-hydroxyphthalimide (NHPI) in supercritical carbon dioxide

Benzylic C(sp3)−H Bond Oxidation with Ketone Selectivity by a Cobalt(IV)‐Oxo Embedded in a β‐Barrel Protein

“…[9][10][11][12][13][14] Until recently, cobalt complexes have barely been known to catalyze CÀ H bond oxidation with high activity. [15][16][17][18][19][20][21][22][23] The mechanism of CÀ H bond oxidation using cobalt catalysts has been shown to involve the formation of a high-valent cobalt(IV)-oxo intermediate, which can abstract a hydrogen atom from the substrate to form a carbon-centered radical that converts alkanes to alcohols and ketones. [16,[24][25][26] Homogeneous biohybrid catalysts, so-called artificial metalloenzymes (ArMs), contain a synthetic metal cofactor attached to the protein scaffold by supramolecular, dative, covalent binding or metal substitutions.…”