Efficient Conversion of Biginelli 3,4‐Dihydropyrimidin‐2(1H)‐one to Pyrimidines via PyBroP‐Mediated Coupling.

5-Alkyl-1,3-Oxazole Derivatives of 6-Amino-Nicotinic Acids as Alkyl Ester Bioisosteres are Antagonists of the P2Y 12 Receptor

“…Surprisingly, only 38 reacted, to give 40, while 39 was recovered from the reaction mixture. Swern oxidation of 40, followed by cyclization with Burgess' reagent and SEM-deprotection with TFA provided 41, which was converted to 34 by reaction with oxalyl chloride [32].…”