Efficient Copper-bisisoquinoline-based Catalysts for Selective Aerobic Oxidation of Alcohols to Aldehydes and Ketones

Abstract

Abstract:The selective oxidation of alcohols with molecular oxygen was efficiently completed in high conversion and selectivity using copper-bisisoquinoline-based catalysts under mild reaction condition. The effects of various parameters such as reaction temperature, reaction time, oxidant, ligands, etc, were studied. Solvent effect has been as well studied in ionic liquids [bmim]PF 6 , [omim]BF 4 and [hmim]BF 4 , comparing to traditional volatile organic solvent. The use of ionic liquids was found to enhance the catalytic properties of the catalysts used.

Activated charcoal: a highly efficient promoter for selective oxidation of alcohols to aldehydes and ketones by K2S2O8 at solvent-free conditions

“…The selective oxidation of primary and secondary alcohols to the corresponding aldehydes and ketones is an important and pivotal reaction in organic synthesis [1][2][3][4] 25 , air/ruthenium cluster 26 , air/copper−bisisoquinoline 27 , air/ruthenium/TEMPO 28 , and polymer−bound Co−oxidants in the presence of TEMPO catalyst 29 are some of the oxidants which have been utilized for such transformation. However, most of the mentioned protocols suffer from several drawbacks in terms of harsh reaction conditions, use of expensive volatile organic solvents, high cost, instability, high toxicity and operational difficulty.…”