Efficient Cross-Coupling Reaction of Aryltrifluoroborates and Aroyl Chlorides for the Synthesis of Fluorine Substituted Aromatic Ketones

Abstract

The direct aroylation of ArCOPdCl with potassium aryltrifluoroborates establishes a new cross-coupling synthetic tool for the synthesis of various fluorine substituted benzophenones. The new microwave irradiated process is very efficient and produce high yield benzophenone products within minutes.arylboronic acids [5] [6]. In this work, a new reaction method establishes for the direct aroylation reaction of potassium aryltrifluoroborates and ArCOCl in the presence of PdCl 2 (Ph 3 P) 2 (Scheme 1).