Body force models of fans and compressors are widely employed for predicting performance due to the reduction in computational cost associated with their use, particularly in nonuniform inflows. Such models are generally divided into a portion responsible for flow turning and another for loss generation. Recently, accurate, uncalibrated turning force models have been developed, but accurate loss generation models have typically required calibration against higher fidelity computations (especially when flow separation occurs). In this paper, a blade profile loss model is introduced which requires the trailing edge boundary layer momentum thicknesses. To estimate the momentum thickness for a given blade section, an artificial neural network is trained using over 400,000 combinations of blade section shape and flow conditions. A blade-to-blade flow field solver is used to generate the training data. The model obtained depends only on blade geometry information and the local flow conditions, making its implementation in a typical computational fluid dynamics framework straightforward. We show good agreement in the prediction of profile loss for 2D cascades both on and off design in the defined ranges for the neural network training.