Efficient detection and assessment of human exposure to trace antibiotic residues in drinking water

Ben, Yujie; Hu, Min; Zhang, Xingyue; Wu, Shimin; Wong, Ming Hung; Wang, Mingyu; Andrews, Charles B.; Chen, Kewei

doi:10.1016/j.watres.2020.115699

Cited by 144 publications

(37 citation statements)

References 47 publications

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“…In particular the MSC denovo (0.004μg/L) was considerably lower than quinolone concentrations found in foodstuffs such as meat products, milk and water in China and elsewhere (Fig. 3) [26-30]. The consumption of foods with high quinolone concentrations has been found to be associated with high urinary and faecal concentrations of quinolones in humans [38-41].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association between quinolone use in food animals and gonococcal resistance to ciprofloxacin: an ecological study

González

Manoharan-Basil

Kenyon

2021

Preprint

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Section: Discussionmentioning

confidence: 99%

“…1)[26-28]. Not even drinking water from taps (median quinolone concentration 0.270 μg/L) [29] and bottled water [30] in China is free of quinolones and other antimicrobials.…”

Section: Introductionmentioning

confidence: 99%

Association between quinolone use in food animals and gonococcal resistance to ciprofloxacin: an ecological study

González

Manoharan-Basil

Kenyon

2021

Preprint

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“…[1][2][3] Many researchers have reported on the occurrence and behavior of APIs in aquatic environments, and the levels of contamination by APIs, including analgesics, antiphlogistics, lipid regulators, and antidepressants in the aquatic environment, with levels ranging from less than a nanogram to micrograms per liter. [1][2][3][4][5] Their presence in drinking water has been reported by WHO, 6) and reported in countries such as the U.S.A., [7][8][9] China, 10) and Japan. 11) Furthermore, the risk they pose to the environment is an established issue.…”

Section: Introductionmentioning

confidence: 90%

Environmental Risk Assessment of Active Human Pharmaceutical Ingredients in Urban Rivers in Japan

Suzuki

Kosugi

Watanabe

et al. 2021

CHEMICAL & PHARMACEUTICAL BULLETIN

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Active pharmaceutical ingredients (APIs) have become a public concern owing to their possible adverse effects on aquatic organisms. Ministry of Health, Labor and Welfare in Japan (MHLW) issued "Guidance on the Environmental Risk Assessment (ERA) in new pharmaceutical development" in 2016. To evaluate the validity of phase 1 in the MHLW's ERA guidance, we monitored the measured environmental concentrations (MECs) of approved APIs in urban rivers and sewage treatment plants (STPs) in Japan and compared these MECs with the predicted environmental concentration (PEC). We collected water samples from urban seven rivers and three STPs during each season. Fifty-one APIs for human and veterinary use and the artificial sweetener sucralose were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Forty-four APIs were observed in the rivers and 42 were found in the influent and effluent of STPs, with levels ranging from nanograms to micrograms per liter. The action limit in phase I of the MHLW's guidance was set to 10 ng/L, and there was no API except for ketoprofen, for which PEC of the MHLW's guidance (PECjapan) was lower than 10 ng/L and the maximum MEC (MECmax) was 10 ng/L or greater. Almost all APIs also had median MECs that were lower than those of the respective PECjapan. These results indicate that the PECjapan values in phase I of the MHLW's guidance were appropriate. However, some APIs had MECmax values that were greater than those of the respective PECjapan due to overestimation of the dilution factor of river water and/or underestimation of API production.

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“…Approximately 30–90% of consumed antibiotics were excreted in urine and faeces as parent compounds and/or metabolites. In addition, 70–80% of the antibiotics used in animal feeding also end up in food due to incomplete removal of antibiotics ( Ben et al, 2019 ). Prolonged exposure of microorganisms to such conditions could transform them into “superbugs”.…”

Section: Introductionmentioning

confidence: 99%

Europium Fluorescent Nanoparticles-Based Multiplex Lateral Flow Immunoassay for Simultaneous Detection of Three Antibiotic Families Residue

Wang

Liu

et al. 2021

Front. Chem.

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A fluorescent immunoassay based on europium nanoparticles (EuNPs-FIA) was developed for the simultaneous detection of antibiotic residues, solving the problems of single target detection and low sensitivity of traditional immunoassay methods. In the EuNPs-FIA, EuNPs were used as indictive probes by binding to anti-tetracyclines monoclonal antibodies (anti-TCs mAb), anti-sulphonamides monoclonal antibodies (anti-SAs mAb) and anti-fluoroquinolones monoclonal antibodies (anti-FQs mAb), respectively. Different artificial antigens were assigned to different regions of the nitrocellulose membrane as capture reagents. The EuNPs-FIA allowed for the simultaneous detection of three classes of antibiotics (tetracyclines, fluoroquinolones and sulphonamides) within 15 min. It enabled both the qualitative determination with the naked eye under UV light and the quantitative detection of target antibiotics by scanning the fluorescence intensity of the detection probes on the corresponding detection lines. For qualitative analysis, the cut-off values for tetracyclines (TCs), fluoroquinolones (FQs) and sulphonamides (SAs) were 3.2 ng/ml, 2.4 ng/ml and 4.0 ng/ml, respectively, which were much lower than the maximum residue limit in food. For quantitative analysis, these ranged from 0.06 to 6.85 ng/ml for TCs, 0.03–5.14 ng/ml for FQs, and 0.04–4.40 ng/ml for SAs. The linear correlation coefficients were higher than 0.97. The mean spiked recoveries ranged from 92.1 to 106.2% with relative standard deviations less than 8.75%. Among them, the three monoclonal antibodies could recognize four types of TCs, seven types of FQs and 13 types of SAs, respectively, and the detection range could cover 24 antibiotic residues with different structural formulations. The results of the detection of antibiotic residues in real samples using this method were highly correlated with those of high performance liquid chromatography (R2 > 0.98). The accuracy and precision of the EuNPs-FIA also met the requirements for quantitative analysis. These results suggested that this multiplex immunoassay method was a promising method for rapid screening of three families of antibiotic residues.

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Efficient detection and assessment of human exposure to trace antibiotic residues in drinking water

Cited by 144 publications

References 47 publications

Association between quinolone use in food animals and gonococcal resistance to ciprofloxacin: an ecological study

Association between quinolone use in food animals and gonococcal resistance to ciprofloxacin: an ecological study

Environmental Risk Assessment of Active Human Pharmaceutical Ingredients in Urban Rivers in Japan

Europium Fluorescent Nanoparticles-Based Multiplex Lateral Flow Immunoassay for Simultaneous Detection of Three Antibiotic Families Residue

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