Efficient determination of non-steroidal anti-inflammatory drugs by micellar electrokinetic chromatography in wastewater

Abstract

Recently, non-steroidal anti-inflammatory drugs (NSAIDs) have been increasingly used by humans and animals. Despite being effective against a wide variety of diseases, they pose a threat to aquatic environments. In...

Determination of some drugs used against neurodegenerative disorders by micellar electrokinetic chromatography with running buffer containing SDS

“…Since the solute migration time in CE depends on its ionisation [14][15][16][17][18], we investigated the influence of the buffer pH on the migration time (Figure 1). For this purpose, four buffer compositions of different pH from 6 to 9 were selected.…”

“…Sodium dodecylsulphate (SDS) is a basic surfactant in many MEKC experiments [14][15][16][17]. This was the main reason for choosing this surfactant for our research.…”

“…We saw that the solute migration time is also affected by organic solvent content in the running buffer [14][15][16]. The influence of acetonitrile concentration on the migration time of the tested substances was examined in the subsequent investigations.…”

Capillary Electrophoresis: A Three-Year Literature Review

“…Typically, nonchiral drugs and their related substances/impurities were predominantly determined with CZE, while chiral separations and optical purity testing were mostly resolved with EKC-based methods (as summarized in the previous Enantiomers section). When dealing with complex samples or those with a complex matrix, MEKC can be utilized to enhance separation selectivity. − Additionally, several innovative (micro)­extraction strategies such as hollow fiber liquid-phase microextraction, direct immersion-single drop microextraction, and electromembrane extraction, along with online stacking techniques such as ITP, FASS, and dynamic pH junction focusing, are frequently used in CE pharmaceutical analysis to improve the detection sensitivity.…”

Preparation and chromatographic evaluation of a mixed polymer brush–silica stationary phase with temperature-sensitive property

“…But very oen, classical singe-mode chromatography, e.g., reversed-phase liquid chromatography (RPLC) for hydrophobic and weak polar compounds, hydrophilic interaction liquid chromatography (HILIC) for highly polar substances, or ion-exchange chromatography (IEC) for charged molecules, are limited in their range of applications. [6][7][8][9] Therefore, achieving the satisfactory separation of many kinds of analytes using one chromatographic column is a desirable goal and has been emphasized in research in separation science. Nowadays, mixed-mode chromatography with multiple retention and excellent separation efficiency has been achieved in one column to separate various types of substances.…”