Efficient electrochemical detection of dopamine with carbon nanocoils and copper tetra(p-methoxyphenyl)porphyrin nanocomposite

Bukhari, Syeda Aqsa Batool; Nasir, Habib; Sitara, Effat; Akhtar, Tehmina; Oduncu, Muhammed Ramazan; Erum, Sadia; Pan, Lujun

doi:10.1016/j.arabjc.2022.104375

Cited by 8 publications

(9 citation statements)

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“…The electroactive surface area of different modified electrodes (bare GCE, TPP, Mn-TPP, RGO, TPP/RGO, and Mn-TPP/RGO) was determined by performing cyclic voltammetry in 0.5 mM K 3 [Fe(CN) 6 ] and 0.1 M phosphate buffer solution (Figure S5). The effective surface area of the electrodes was calculated by using the Randles–Sevcik equation , as given below: I p = 2.69 × 10 5 × A × D 1 / 2 × υ 1 / 2 × n 3 / 2 × C 0 where I p represents the peak current in amperes; A designates the effective surface area (ESA); D is the distribution coefficient of the redox probe [Fe(CN) 6 ] −3/ –4 , i.e., 7.6 × 10 –6 cm 2 s –1 ; υ represents the scan rate in V/s; n designates the number of electrons; and C 0 refers to the concentration of [Fe(CN) 6 ] −3/ –4 in mol/L. The ESAs of bare GCE, TPP, Mn-TPP, RGO, TPP/RGO, and Mn-TPP/RGO were found to be 0.37, 0.10, 0.16, 0.15, 0.39, and 0.43 cm 2 , respectively.…”

Section: Resultsmentioning

confidence: 99%

“…The sensitivity of the electrode was estimated by dividing the value of the slope (obtained from the calibration curve between peak current I pa and concentration of analyte DOX) by the electroactive surface area of the electrode. Similarly, the limit of detection (LoD) and limit of quantification (LoQ) were obtained by and , respectively LoD = 3 × false( standard 0.25em deviation 0.25em of 0.25em blank false) slope 0.25em obtained 0.25em from 0.25em concentration 0.25em studies 0.25em of 0.25em analyte LoQ = 10 × false( standard 0.25em deviation 0.25em of 0.25em blank false) slope 0.25em obtained 0.25em from 0.25em concentration 0.25em studies 0.25em of 0.25em analyte …”

Section: Methodsmentioning

confidence: 99%

“…Similarly, the limit of detection (LoD) and limit of quantification (LoQ) were obtained by and 2, respectively. 33 = × LoD 3 (standard deviation of blank) slope obtained from concentration studies of analyte Methodology. Synthesis of Manganese(II) Tetraphenylporphyrin.…”

Section: ■ Introductionmentioning

confidence: 99%

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Fabrication of Mn-TPP/RGO Tailored Glassy Carbon Electrode for Doxorubicin Sensing

Zafar,

Bukhari,

Nasir

2024

ACS Omega

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Cancer is a long-standing disease, and the use of anticancer drugs can cause many different harmful side effects. Therefore, the quantitative analysis of anticancer drugs is crucial. Among all the analytical techniques that have been utilized for the detection of doxorubicin, electrochemical sensors have drawn exceptional consideration because they are simple, affordable, and highly sensitive. Manganese tetraphenylporphyrin decorated reduced graphene oxide (Mn-TPP/RGO), tetraphenylporphyrin decorated reduced graphene oxide (TPP/RGO), and reduced graphene oxide (RGO) nanostructure based glassy carbon electrodes (GCEs) were fabricated for the detection of doxorubicin (DOX). The synthesized materials were characterized by FTIR, scanning electron microscopy (SEM), ultraviolet−visible spectroscopy (UV/vis), energy dispersive X-ray spectroscopy (EDS), and X-ray diffraction (XRD). Doxorubicin detection was performed using differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS), and cyclic voltammetry (CV). Among the prepared electrodes, Mn-TPP/RGO modified GCE gave an optimum peak current at pH 3. The Mn-TPP/RGO modified electrode showed significant linear response range (0.1−0.6 mM); effective sensitivity (112.09 μA mM −1 cm −2 ); low detection limit (63.5 μM); and excellent stability, selectivity, repeatability, and reproducibility toward doxorubicin. With differential pulse voltammetry, LoD and sensitivity were 27 μM and 0.174 μA μM −1 cm −2 , respectively. Real sample analysis was also performed in human serum, and it depicted reasonable recovery results for spiked doxorubicin.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Fabrication of Mn-TPP/RGO Tailored Glassy Carbon Electrode for Doxorubicin Sensing

Zafar,

Bukhari,

Nasir

2024

ACS Omega

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“…In this section we will discuss some of the sensors used for the detection of amino acids (L-Tryptophan, L-Tyrosine, L-Cysteine, L-Histidine), [132,133] volatile organic compounds (VOCs), [134][135][136][137][138] herbicides (dimethoate, methyl parathion, glyphosate), [139,140] relevant organic acids (nicotinic, pipecolic, uric, folic, sorbic and ascorbic acid), [141][142][143][144][145][146][147] polyphenols, [148][149][150][151] pharmaceutical compounds (sildenafil citrate, sulfadiazine, sulfamethoxazole, isoniazid, chloramphenicol, ibuprofen, trimethoprim, diclofenac, acetaminophen), [151][152][153][154] and hormones and neurotransmitters (cortisol, 17β-estradiol, levodopa, carbidopa, dopamine). [145,147,[155][156][157][158] The detection methods for amino acids and pharmaceutical compounds have been described in detail in the reviews of Cruz-Navarro et al [19] and Gonçalves et al [159] For a more detailed description of all compounds see Table S1.…”

Section: Biological Pharmaceutical and Environmental Medium-sized Int...mentioning

confidence: 99%

Versatile Metalloporphyrin‐Based Electrochemical Sensing Applications: From Small Gasotransmitters to Macromolecules

2023

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At the beginning of his youthful sixth decade, this work is dedicated to Prof. Dr. Fabio Doctorovich. He is distinctive in organometallic chemistry. During his successful career, he has been studying the reactivity and application of metalloporphyrins. Metalloporphyrins are organometallic complexes that exhibit, through synthetic modifications, the ability to tune their optical and electrochemical properties and their selectivity towards a particular molecule or ion. For this reason, they are systems extremely useful as electrochemical sensors to detect and quantify a wide variety of analytes with high selectivity, even in real samples such as food, water, biological fluids, or pharmaceutical compounds. This review presents an up-to-date list of reports in which metalloporphyrins are used as electrochemical sensors. In addition to compiling a comprehensive and up-to-date list of reported sensors that utilize metalloporphyrins, this work aims to provide an overview of currently available tools and techniques for the detection of various chemical species through similar approaches, which are constantly being developed.

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“…Due to their unique properties, copper phthalocyanines (CuPcs) have demonstrated signi cant potential in various bio-applications. In biosensing, CuPcs are utilized for their strong a nity to speci c biomolecules, enabling highly sensitive and selective detection of DNA sequences, proteins, and neurotransmitters [11][12][13][14][15]. Their electrochemical characteristics make them ideal for developing biosensors with rapid response times.…”

Section: Introductionmentioning

confidence: 99%

Iodine Coadsorbed OH-Copper Phthalocyanine for Dopamine Sensing – A DFT Study

Sangeetha,

Lakshmipathi

2024

Preprint

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Density Functional Theory (DFT) was employed to investigate the sensing behavior of the neurotransmitter dopamine (DA) when interacting with OH-functionalized copper phthalocyanines (CuPCs) and copper phthalocyanines coadsorbed with iodine (CuIPc), both in gaseous and aqueous media. The study revealed that CuIPc demonstrates a superior capacity for detecting dopamine molecules compared to CuPc. Within these complexes, hydrogen bonds and coordination bonds were observed, with hydrogen bonds playing a pivotal role in the dopamine adsorption process. The enhanced electrical conductivity of CuPc sheets after iodine adsorption, along with the high adsorption energy of the iodine-coadsorbed CuPc/DA complexes, underscores the significance of iodine in this context. It is noteworthy that the utilization of iodine significantly enhances the sensing response for dopamine. In summary, copper phthalocyanine coadsorbed with iodine emerges as a promising material for dopamine sensors, offering possibilities for further advancements in this field.

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Efficient electrochemical detection of dopamine with carbon nanocoils and copper tetra(p-methoxyphenyl)porphyrin nanocomposite

Cited by 8 publications

References 57 publications

Fabrication of Mn-TPP/RGO Tailored Glassy Carbon Electrode for Doxorubicin Sensing

Fabrication of Mn-TPP/RGO Tailored Glassy Carbon Electrode for Doxorubicin Sensing

Versatile Metalloporphyrin‐Based Electrochemical Sensing Applications: From Small Gasotransmitters to Macromolecules

Iodine Coadsorbed OH-Copper Phthalocyanine for Dopamine Sensing – A DFT Study

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