Efficient focusing of microwave hyperthermia for small deep-seated breast tumors treatment using particle swarm optimization

Elkayal, Heba Abdelhamid; Ismail, Nour Eldin

doi:10.1080/10255842.2020.1863379

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…This enables conformal tumor heating by mechanically or electronically scanning a highly focused beam through the target region at various breast locations [ 12 , 15 ]. Moreover, efficient HT focusing can be achieved for small deep-seated breast tumors utilizing radiating elements implemented in a symmetric cross configuration [ 16 , 17 ]. In [ 18 , 19 ] a Cross—array (

) arrangement of four sub-arrays of corrugated tapered slot antennas for application in three-dimensional (3D) HT was investigated using MRI-derived realistic 3D breast phantoms in full-wave electromagnetic simulations.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Microwave Hyperthermia Applicator Designs with Fora Dipole and Connected Array

Yildiz

Farhat

Farrugia

et al. 2023

Sensors

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In microwave hyperthermia tumor therapy, electromagnetic waves focus energy on the tumor to elevate the temperature above its normal levels with minimal injury to the surrounding healthy tissue. Microwave hyperthermia applicator design is important for the effectiveness of the therapy and the feasibility of real-time application. In this study, the potential of using fractal octagonal ring antenna elements as a dipole antenna array and as a connected array at 2.45 GHz for breast tumor hyperthermia application was investigated. Microwave hyperthermia treatment models consisting of different fractal octagonal ring antenna array designs and a breast phantom are simulated in COMSOL Multiphysics to obtain the field distributions. The antenna excitation phases and magnitudes are optimized using the global particle swarm algorithm to selectively increase the specific absorption rate at the target region while minimizing hot spots in other regions within the breast. Specific absorption rate distributions, obtained inside the phantom, are analyzed for each proposed microwave hyperthermia applicator design. The dipole fractal octagonal ring antenna arrays are comparatively assessed for three different designs: circular, linear, and Cross—array. The 16-antenna dipole array performance was superior for all three 1-layer applicator designs, and no distinct difference was found between 16-antenna circular, linear, or cross arrays. Two-layer dipole arrays have better performance in the deep-tissue targets than one-layer arrays. The performance of the connected array with a higher number of layers exceeds the performance of the dipole arrays in the superficial regions, while they are comparable for deep regions of the breast. The 1-layer 12-antenna circular FORA dipole array feasibility as a microwave hyperthermia applicator was experimentally shown.

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Section: Introductionmentioning

confidence: 99%

Comparison of Microwave Hyperthermia Applicator Designs with Fora Dipole and Connected Array

Yildiz

Farhat

Farrugia

et al. 2023

Sensors

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“…Second, because of the variable shape and size of tumors, the antennas cannot precisely match the tumor boundaries. Therefore, normal tissue damage is inevitable during tumor MW hyperthermia. − At the same time, a miniaturized focused waveguide can effectively solve this problem by focusing MW energy on the tumor site to efficiently control local temperature, maximize microwave energy in the tumor area, and minimize the damage to normal tissues.…”

Section: Introductionmentioning

confidence: 99%

Micro-Opening Ridged Waveguide Tumor Hyperthermia Antenna Combined with Microwave-Sensitive MOF Material for Tumor Microwave Hyperthermia Therapy

Jin

Sun

et al. 2022

ACS Appl. Bio Mater.

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Microwave hyperthermia is an emerging minimally invasive therapy in which thermal damage and apoptosis of tumor cells are induced by local heating of tissues with microwave radiation. Recently, microwave hyperthermia has been widely used in clinical practice; however, uneven aggregation and dispersion of malignant tumors after microwave hyperthermia are the main problems associated with this method. In this work, a microridged waveguide tumor hyperthermia antenna with an operating frequency of 915 MHz was designed. Although its volume is only 6.6 cm 3 , it exhibited a highly focused heating effect, achieving rapid heating in a small area. However, microwave hyperthermia has several shortcomings. Microwaves cannot specifically identify and target tumors; this decreases the efficiency of the treatment if the temperature of the tumor site is not sufficiently high for its size and location. Therefore, Zr metal−organic framework (ZrMOF)-derived composite ZCNC was synthesized using the ultrasonic aerosol flow method, which has good microwave sensitization and biosafety. ZCNC reduced the damage to normal cells and greatly improved the tumor treatment effect of microwave hyperthermia (tumor inhibition rate reached 78.01%). Thus, the proposed strategy effectively improves the current clinical microwave hyperthermia treatment method.

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Synergistic microwave hyperthermia treatment for subcutaneous deep in situ breast cancer using conformal array antennas and a microwave-thermal-sensitive nanomaterial

Zhang,

Du,

Qin

et al. 2025

J. Mater. Chem. B

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Efficient focusing of microwave hyperthermia for small deep-seated breast tumors treatment using particle swarm optimization

Cited by 6 publications

References 12 publications

Comparison of Microwave Hyperthermia Applicator Designs with Fora Dipole and Connected Array

Comparison of Microwave Hyperthermia Applicator Designs with Fora Dipole and Connected Array

Micro-Opening Ridged Waveguide Tumor Hyperthermia Antenna Combined with Microwave-Sensitive MOF Material for Tumor Microwave Hyperthermia Therapy

Synergistic microwave hyperthermia treatment for subcutaneous deep in situ breast cancer using conformal array antennas and a microwave-thermal-sensitive nanomaterial

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