Efficient formation and maintenance of humoral and CD4 T-cell immunity targeting the viral capsid in acute-resolving hepatitis E infection

Csernalabics, Benedikt; Marinescu, Mircea Stefan; Maurer, Lars; Kelsch, Lara; Werner, Jill; Baumann, Katharina; Zoldan, Katharina; Panning, Marcus; Reuken, Philipp; Bruns, Tony; Bengsch, Bertram; Neumann-Haefelin, Christoph; Hofmann, Maike; Thimme, Robert; Dao Thi, Viet Loan; Boettler, Tobias

doi:10.1016/j.jhep.2023.12.016

Journal of Hepatology

2024

DOI: 10.1016/j.jhep.2023.12.016

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Efficient formation and maintenance of humoral and CD4 T-cell immunity targeting the viral capsid in acute-resolving hepatitis E infection

Benedikt Csernalabics,

Mircea Stefan Marinescu,

Lars Maurer

et al.

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Cited by 1 publication

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Multiple Functions of Hepatitis E Virus ORF3

Jiao,

Zhao,

Zhou

et al. 2024

Microorganisms

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Hepatitis E (Hepatitis E, HE) is an acute and chronic infectious hepatitis caused by hepatitis E virus (Hepatitis E Virus, HEV) infection, which is responsible for most acute hepatitis in the world and is a significant public health problem. The pathogen, HEV, has three Open Reading Frames (ORFs) ORF1, ORF2, and ORF3, each of which has a different function. Most of the current research is focused on ORF1 and ORF2, while the research on ORF3 is still relatively small. To provide more ideas for the study of HEV pathogenesis and the prevention and treatment of HE, this paper reviews the effects of ORF3 on the ERK pathway, growth factors, immune response, and virus release.

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Multiple Functions of Hepatitis E Virus ORF3

Jiao,

Zhao,

Zhou

et al. 2024

Microorganisms

View full text Add to dashboard Cite

show abstract

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Efficient formation and maintenance of humoral and CD4 T-cell immunity targeting the viral capsid in acute-resolving hepatitis E infection

Cited by 1 publication

References 37 publications

Multiple Functions of Hepatitis E Virus ORF3

Multiple Functions of Hepatitis E Virus ORF3

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