2005
DOI: 10.1016/j.exphem.2005.07.006
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Efficient gene transfer into primary human natural killer cells by retroviral transduction

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Cited by 48 publications
(32 citation statements)
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References 223 publications
(217 reference statements)
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“…Cell lines of the lymphoid lineage are difficult to transfect efficiently and to establish long-lasting transgene expression using retroviruses, diethylaminoethyl dextran, or liposomes (Guven et al ., 2005). Therefore, a doxycycline-inducible lentiviral vector system, pTRIPZ was used to establish all SKW clones (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Cell lines of the lymphoid lineage are difficult to transfect efficiently and to establish long-lasting transgene expression using retroviruses, diethylaminoethyl dextran, or liposomes (Guven et al ., 2005). Therefore, a doxycycline-inducible lentiviral vector system, pTRIPZ was used to establish all SKW clones (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…10-fold [146]. Guven et al reported transduction into 75.4% of NK cells after 21 days of culture by a two-round transduction with the GALV-pseudotyped retroviral vector [147]. Further improvement of the transduction efficiency into NK cells by using viral vectors is desired.…”
Section: Genetic Modification-gene Transfer To Nk Cellsmentioning
confidence: 99%
“…Introduction of genes expressing various cytokines for enhancement of in vivo survival and cytotoxicity of adoptively transferred NK cells are also among various approaches. Although transient methods such as electroporation (Grund and Muise-Helmericks 2005;Schoenberg et al, 2008;Boissel et al, 2009) or nucleofection (Trompeter et al, 2003) applications are under significant improvement, stable transduction using retroviral (Nagashima et al, 1998;Uherek et al, 2002;Becknell et al, 2005;Guven et al, 2005;Imai et al, 2005;Konstantinidis et al, 2005;Alici et al, 2009) or lentiviral (Karimi et al, 2005;Baeriswyl et al, 2006;Micucci et al, 2006;Tran and Kung, 2007;Figueiredo et al, 2009;Kung, 2010;Tran et al, 2010) vectors present greater advantage in terms of long-term effects and sustainability.…”
Section: Introductionmentioning
confidence: 99%