Efficient gene transfer using the human JC virus-like particle that inhibits human colon adenocarcinoma growth in a nude mouse model

High-Throughput Screening Identifies a Bisphenol Inhibitor of SV40 Large T Antigen ATPase Activity

“…A role for JC virus in gastrointestinal malignancies has also been suggested recently. 2 BK virus establishes a lifelong persistent infection in kidney epithelial cells, and reactivation within these cells results in a lytic infection in immunocompromised patients. BK virus is also urotheliotropic and causes interstitial nephritis, known as BK- or PyV-associated nephropathy, which is associated with high graft loss if not recognized and treated early.…”

Recombinant VLP-Z of JC Polyomavirus: A Novel Vector for Targeting Gene Delivery

“…The JCPyV receptor is expressed in a wide range of cells of many species, as well as humans [9]. Thus, the transduction mediated by wild-type (wt) VLP is not cell specific [7].…”

“…It has been shown that Escherichia coli -expressed VP 1 is able to self-assemble into a capsid-like particle and deliver exogenous DNA into human kidney cells [8]. In vivo, VLP has been used to increase efficiency of gene transfer [9]. …”

Targeting the IL-10 Pathway by RNA Interference Has Beneficial Effects on the Development of Experimental Lupus

“…In vitro, gene transduction efficiency with JC VLPs is approximately 200 times higher than delivery by liposomes (21). In a mouse model, JC virus VLPs were used to achieve high efficiency gene transfer, to specifically target human colon carcinoma cells, and to greatly reduce tumor volume (22). In addition, JC virus VLPs are able to package small molecules, such as oligonucleotides or other chemical compounds, at high efficiency (23,24).…”