2011
DOI: 10.1016/j.vaccine.2011.05.069
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Efficient influenza B virus propagation due to deficient interferon-induced antiviral activity in MDCK cells

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Cited by 17 publications
(7 citation statements)
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“…While previous studies have established the effects of human MxA(19) or mouse Mx1(20) proteins against human and avian IAVs, our study demonstrates an in vivo role for murine Mx1 in restricting IBV replication. This is consistent with previous reports of reduced IBV polymerase activity in the presence of Mx1 in an in vitro minireplicon system(21). Our experiments further show that Mx-mediated suppression may contribute to restriction of IBV to the URT.…”
Section: Discussionsupporting
confidence: 93%
“…While previous studies have established the effects of human MxA(19) or mouse Mx1(20) proteins against human and avian IAVs, our study demonstrates an in vivo role for murine Mx1 in restricting IBV replication. This is consistent with previous reports of reduced IBV polymerase activity in the presence of Mx1 in an in vitro minireplicon system(21). Our experiments further show that Mx-mediated suppression may contribute to restriction of IBV to the URT.…”
Section: Discussionsupporting
confidence: 93%
“…It is very important to notice that in the present case, the comparison of the MOI conditions is based only on the IVP produced. A significant number of reports describing the development of influenza cell‐based production focus rather on the total HA antigen production levels (log HA units) 49, 51–55. Therefore, direct comparison might be difficult.…”
Section: Resultsmentioning
confidence: 99%
“…A previous study also demonstrated that IFN expression suppressed the replication of different viruses, including murine NoV [ 47 ]. On the other hand, unlike immune cell and in vivo studies, MDCK cells could not demonstrate IFN-induced antiviral activity against influenza virus, which could subsequently lower antiviral defense in the cells, and promote virus replication [ 48 , 49 ]. Furthermore, ISG15 regulates the IFN -mediated antiviral immune response against different viruses, including murine NoV, influenza A, hepatitis C, and dengue viruses by covalently conjugating (ISGylation) to viral or cellular proteins to inhibit virus replication [ 50 , 51 ].…”
Section: Discussionmentioning
confidence: 99%