Efficient Liquid/Liquid Extraction by a Milli Device Based on Hydrophobic Membranes

Wellsandt, T.; Stanisch, B.; Strube, Jochen

doi:10.1002/cite.201550036

Cited by 1 publication

(1 citation statement)

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“…To broaden the availability of demonstrators of model-based process developments, a wide variety of substance combinations and solvent systems is continuously investigated, also with different extraction equipment. Examples are the utilization of ATPS (aqueous two-phase systems) for the extraction of botanicals or biologicals, such as monoclonal antibodies (mabs) in single or multi stage mixer-settlers and columns [11][12][13][14], the development and characterization of highly innovative prototypes, like membrane-supported liquid-liquid extractors [15,16] or model-based identification of the most efficient and sustainable purification strategy for strategic metals, like rare earth elements, by LLE-chromatography hybrid separation [17].…”

Section: Model-based Process Development Strategymentioning

confidence: 99%

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part II: Model-Based Design of Agitated and Packed Columns for Multistage Extraction and Scrubbing

et al. 2018

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Liquid-liquid extraction (LLE) is an established unit operation in the manufacturing process of many products. However, development and integration of multistage LLE for new products and separation routes is often hindered and is probably more cost intensive due to a lack of robust development strategies and reliable process models. Even today, extraction columns are designed based on pilot plant experiments. For dimensioning, knowledge of phase equilibrium, hydrodynamics and mass transport kinetics are necessary. Usually, those must be determined experimentally for scale-up, at least in scales of DN50-150 (nominal diameter). This experiment-based methodology is time consuming and it requires large amounts of feedstock, especially in the early phase of the project. In this study the development for the integration of LLE in a new manufacturing process for artemisinin as an anti-malaria drug is presented. For this, a combination of miniaturized laboratory and mini-plant experiments supported by mathematical modelling is used. System data on extraction and washing distributions were determined by means of shaking tests and implemented as a multi-stage extraction in a process model. After the determination of model parameters for mass transfer and plant hydrodynamics in a droplet measurement apparatus, a distributed plug-flow model is used for scale-up studies. Operating points are validated in a mini-plant system. The mini-plant runs are executed in a Kühni-column (DN26) for extraction and a packed extraction column (DN26) for the separation of side components with a throughput of up to 3.6 L/h, yield of up to 100%, and purity of 41% in the feed mixture to 91% after washing.

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