Efficient molecular packing of glycerol monostearate in Langmuir monolayers at the air-water interface

Pantoja-Romero, Wenndy S.; Estrada-López, Evelina D.; Picciani, Paulo H. S.; Oliveira, Osvaldo N.; Lachter, Elizabeth R.; Pimentel, André Silva

doi:10.1016/j.colsurfa.2016.08.016

Cited by 16 publications

(9 citation statements)

References 47 publications

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“…Due to its antibacterial properties, GMC is regarded as a new type of non-toxic and highly effective broad-spectrum food preservative by the National Health Commission of the People’s Republic of China. Moreover, GMC has excellent emulsifying properties, which are helpful for stabilizing food shape, improving tissue structure, and optimizing product quality [ 1 ]. GMC with these effective antibacterial and emulsifying properties has been widely used in a variety of foods, such as wet-fresh noodles, pastry, and meat [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Glycerol Monocaprylate Modulates Gut Microbiota and Increases Short-Chain Fatty Acids Production without Adverse Effects on Metabolism and Inflammation

2021

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Glycerol monocaprylate (GMC) is a glycerol derivative of medium-chain fatty acids (MCFAs) and is widely used as a preservative in food processing. However, GMC and its hydrolytic acid (octylic acid) have antibacterial properties that may affect the physiology and intestinal microecology of the human body. Therefore, in this study, the effects of two different dosages of GMC (150 and 1600 mg kg−1) on glucose, lipid metabolism, inflammation, and intestinal microecology of normal diet-fed C57BL/6 mice were comprehensively investigated. The obtained results showed that the level of triglycerides (TGs) in the low-dose group down-regulated significantly, and the anti-inflammatory cytokine interleukin 10 (IL-10) significantly increased, while the pro-inflammatory cytokines monocyte chemotactic protein 1 (MCP-1) and interleukin 1beta (IL-1β) in the high-dose group were significantly decreased. Importantly, GMC promoted the α-diversity of gut microbiota in normal-diet-fed mice, regardless of dosages. Additionally, it was found that the low-dose treatment of GMC significantly increased the abundance of Lactobacillus, while the high-dose treatment of GMC significantly increased the abundance of SCFA-producers such as Clostridiales, Lachnospiraceae, and Ruminococcus. Moreover, the content of short-chain fatty acids (SCFAs) was significantly increased by GMC supplementation. Thus, our research provides a novel insight into the effects of GMC on gut microbiota and physiological characteristics.

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Section: Introductionmentioning

confidence: 99%

Glycerol Monocaprylate Modulates Gut Microbiota and Increases Short-Chain Fatty Acids Production without Adverse Effects on Metabolism and Inflammation

2021

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“…Bibliographic references to previous studies can be found in [1][2][3]. Articles on single component fatty acids or related amphiphiles published in the last years are those of [4][5][6][7][8][9][10][11][12][13][14][15][16], and articles on single component phospholipids are those of [17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Thermodynamic Behaviour of Mixed Films of an Unsaturated and a Saturated Polar Lipid. (Oleic Acid-Stearic Acid and POPC-DPPC)

Torrent‐Burgués

2018

Colloids and Interfaces

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Mixed fatty acids or mixed phospholipids systems with saturated-unsaturated hydrocarbon chains are of biological interest. In this work, the monolayers of oleic acid-stearic acid (OA-SA) and palmitoyloleoylphosphatidylcholine-dipalmitoylphosphatidylcholine (POPC-DPPC) have been studied. From the surface pressure-area isotherms, elastic modulus values and virial equation coefficients can be obtained. Thermodynamic treatment also yields excess (G E ) and mixing (∆G mix ) free energies. Results indicate positive G E values, that is, molecular interactions in the mixed films are less favourable, due to the presence of unsaturation; however, the mixture is slightly favourable due to the entropic factor that affords positive ∆G mix values. For the OA-SA system, a high SA content and surface pressure facilitate the phase separation, even though a certain miscibility between both components still remains. For the POPC-DPPC system, the most favourable mixing conditions occur for X POPC ≈ 0.4. For these mixed systems, the values of the elastic modulus are more similar to those of more fluid components (OA or POPC); analysis of the virial coefficients shows that the b 1 virial coefficient values lie between those of the individual components and are higher than values suitable for an ideal mixing.

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“…4 GMS has been used as a lubricant, emollient, protective coating in hygroscopic powders, solidifier, dispersant, and for drug release in applications for the pharmaceutical, cosmetics, plasticizer, and other industries. 28,30 The amphiphilic nature of GMS as well as its small molecular weight enables it to readily self-assemble at the oil-water interface and form a number of mesophases. 31,32 The solid crystal phase formed by GMS allows it to form highly-stable core-shell type emulsion droplets where dispersed aqueous droplets are surrounded by a crystalline shell.…”

Section: Surfactantsmentioning

confidence: 99%

In-vitro Digestion Of Fat Crystal-Stabilized Water-In-Oil Emulsions

Patel¹

2021

Preprint

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The purpose of this research was to investigate the effect of surfactant type and presence of solid fat on the stability and release characteristics of water-in-oil (W/O) emulsions subjected to simulated gastrointestinal conditions. Emulsions consisting of a 20 wt% aqueous phase dispersed in canola oil were stabilized in one of four different ways: core-shell stabilization with glycerol monostearate (GMS), network stabilization using polyglycerol polyricinoleate and solid fat added to the continuous phase (PGPR-F), combined core-shell and network stabilization using glycerol monooleate and a continuous phase fat crystal network (GMO-F) and finally, a PGPR-based liquid emulsion with no added fat. The dispersed aqueous phase of all emulsions contained 1mM methylene blue (MB), which was used as a marker to quantify emulsion breakdown and release of aqueous phase cargo. Quiescent storage at 25 °C for 30 days revealed no phase separation for the GMS, GMO-F, and PGPR-F emulsions whereas the PGPR emulsion began to phase-separate 16 h following preparation. When subjected to gastric conditions, the PGPR-F emulsion showed the lowest MB release after 60 min (0.3 % of initial load) with the other emulsions showing ~ 12 % release. In duodenal conditions, the PGPRF and GMS emulsions showed the lowest MB release after 120 min of exposure (~ 0.5 %) followed by the PGPR (9.4 %) and GMO-F (14.6 %) emulsions, respectively. Emulsion photomicrographs taken prior to, and after, contact with simulated gastric and intestinal fluids showed that emulsion microstructure was an important contributor to emulsion stability. Overall, the PGPR-F emulsion was the most stable in both gastric and intestinal fluids. These results have shown that fat phase structuring is an important contributor to W/O emulsion breakdown behaviour in simulated gastrointestinal conditions.

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Efficient molecular packing of glycerol monostearate in Langmuir monolayers at the air-water interface

Cited by 16 publications

References 47 publications

Glycerol Monocaprylate Modulates Gut Microbiota and Increases Short-Chain Fatty Acids Production without Adverse Effects on Metabolism and Inflammation

Glycerol Monocaprylate Modulates Gut Microbiota and Increases Short-Chain Fatty Acids Production without Adverse Effects on Metabolism and Inflammation

Thermodynamic Behaviour of Mixed Films of an Unsaturated and a Saturated Polar Lipid. (Oleic Acid-Stearic Acid and POPC-DPPC)

In-vitro Digestion Of Fat Crystal-Stabilized Water-In-Oil Emulsions

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