In this paper, we propose a post-layout waveform prediction method by System Identification (SI) based on the fact that the waveforms of pre-layout and post-layout are always correlated. Mathematical models are built to describe the relationships between the pre-layout and post-layout simulation results via SI techniques. The model parameters are calibrated by using the simulation results of the first few data points of pre-layout and post-layout stages. By taking the corresponding pre-layout simulation results as inputs of the calibrated models, the rest postlayout waveforms can thus be predicted as the output of the models. Several examples demonstrate the efficiency of the prediction, which helps the designers have a quick view of the post-layout waveforms in the design process.