At present, in the cloud computing environment, the massive data has different attribute characteristics, which cannot be made balance scheduling. There are often long scheduling time, and the balance of CPU, memory and bandwidth is poor. Based on the improved clonal selection algorithm, the balance scheduling method for massive data in cloud computing environment is proposed. Firstly, the massive data balance loading and scheduling, as well as the minimized task execution time are taken as the target, to construct the data scheduling model in the cloud computing environment. According to the principle of clonal selection, the attributes of the massive data in the cloud computing environment are defined as antigens, and the antibody encoding mode of the massive data balance scheduling is designed. Meanwhile, the individual data with the higher affinity to the antigens are selected from the antibody for mutation treatment, and the balance of massive data scheduling is quantified in cloud computing environment. After obtaining the quantization function, the control parameters of massive data scheduling are analyzed and studied, so as to build a balance scheduling model for massive data in cloud computing environment. The simulation results show that the proposed algorithm can make effectively balance scheduling for the massive data in the cloud computing environment, its scheduling time is short, the balance of CPU, memory and bandwidth is higher and the reliability is strong.