In this research, A zone‐based failure risk assessment (FRA) method of fatigue crack growth (FCG) caused by initial defects in the FGH96 alloy turbine disc is developed. Firstly, the initial defects distribution in the FGH96 alloy turbine disc is calculated based on the defect data. Subsequently, a probabilistic short FCG life model is established, taking into account the dispersion in grain size. Meanwhile, a probabilistic long FCG life model is established, incorporating the life dispersion factor. To calculate the Stress Intensity Factor (SIF) at any position of the disc, the general weight function method and the rectangular plate model are established. Finally, the zoning process is established, enabling a FRA that considers the FCG due to initial defects. The results indicate that the number of cycles corresponding to a 0.13% failure probability of the turbine disc is 7150, and the percentage of failures in each zone is analyzed.