2008
DOI: 10.1016/j.tetlet.2008.03.075
|View full text |Cite
|
Sign up to set email alerts
|

Efficient one-pot synthetic approaches for cannabinoid analogues and their application to biologically interesting (−)-hexahydrocannabinol and (+)-hexahydrocannabinol

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
28
0
1

Year Published

2008
2008
2023
2023

Publication Types

Select...
9

Relationship

2
7

Authors

Journals

citations
Cited by 56 publications
(29 citation statements)
references
References 24 publications
0
28
0
1
Order By: Relevance
“…For this reason, Brønsted acids were employed in our new methodology for the preparation of various benzopyrans [25][26][27][28][29][30][31][32][33][34]. As a part of our ongoing evaluation of the synthetic efficacy of Brønsted acids, we first investigated the reaction of b-enaminone 1a with 3-methyl-2-butenal using several Brønsted acids, but also Lewis acids and other reagents ( Table 1).…”
Section: Resultsmentioning
confidence: 99%
“…For this reason, Brønsted acids were employed in our new methodology for the preparation of various benzopyrans [25][26][27][28][29][30][31][32][33][34]. As a part of our ongoing evaluation of the synthetic efficacy of Brønsted acids, we first investigated the reaction of b-enaminone 1a with 3-methyl-2-butenal using several Brønsted acids, but also Lewis acids and other reagents ( Table 1).…”
Section: Resultsmentioning
confidence: 99%
“…11) Therefore, HIF-1α and other factors interacting with HIF-1α have been suggested as therapeutic targets for anti-cancer drug development. 12,13) We recently synthesized and evaluated the anti-cancer effects of a novel series of hexahydrocannabinol analogs. [14][15][16] Of these analogs, LYR-8, a cannabinoid-like compound with no affinity for conventional cannabinoid receptors (CB 1 and CB 2 ), was found to directly inhibit the growth, induce apoptosis of cancer cells and inhibit endothelial cell proliferation and angiogenesis.…”
mentioning
confidence: 99%
“…11 As an expansion of the synthesis of benzopyrans and cannabinoid, (±)-perrottetinene (4) was concisely synthesized in this study.…”
mentioning
confidence: 99%