Photodetectors are critical components for various electronic applications. Compared with traditional photodetectors based on inorganic materials, organic photodetectors have received an increasing amount of attention because of the features of tunable energy levels, solution-preparation, and flexibility. Owing to higher exciton binding energy and smaller carrier mobility, it is impossible to obtain photomultiplication type organic photodetectors (PM-OPDs) directly using the same working mechanism of avalanche photodiodes or photomultiplier tubes. This review details the latest strategies for realizing the photomultiplication phenomenon in organic photodetectors including doping to introduce traps, acceptor materials as traps, and the introduction of interfacial blocking layers. Afterwards, we detail the tuning strategies of the response spectra range of the PM-OPDs for different application scenarios.