2024
DOI: 10.21203/rs.3.rs-3633932/v1
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Efficient palladium-catalyzed electrocarboxylation enables late-stage carbon isotope labelling

Troels Skrydstrup,
Gabriel Batista,
Ruth Ebenbauer
et al.

Abstract: Carbon isotope labelling of bioactive molecules is a critical step for accessing the pharmacokinetic and pharmacodynamic properties of new drug entities. Aryl carboxylic acids represent an important class of structural motifs commonly found in many pharmaceutically active molecules and are ideal target structures for the installation of a radioactive tag employing isotopically labelled CO2. However, direct isotope incorporation via the reported catalytic reductive carboxylation (CRC) of aryl electrophiles reli… Show more

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