Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles

Abstract

Indocyanine green (ICG), a near-infrared (NIR) fluorescent dye approved by the Food and Drug Administration (FDA), has been extensively used as a photoacoustic (PA) probe for PA imaging. However, its practical application is limited by poor photostability in water, rapid body clearance, and non-specificity. Herein, we fabricated a novel biomimetic nanoprobe by coating ICG-loaded mesoporous silica nanoparticles with the cancer cell membrane (namely, CMI) for PA imaging. This probe exhibited good dispersion, large loading efficiency, good biocompatibility, and homologous targeting ability to Hela cells in vitro. Furthermore, the in vivo and ex vivo PA imaging on Hela tumor-bearing nude mice demonstrated that CMI could accumulate in tumor tissue and display a superior PA imaging efficacy compared with free ICG. All these results demonstrated that CMI might be a promising contrast agent for PA imaging of cervical carcinoma.

Multimodal optoacoustic imaging: methods and contrast materials

“…60 Hybrid OA-FL can also be performed with particulate agents, e.g. quantum dots (QDs), 118 gold nanorods (GNRs), 119 carbon nanotubes, 120 FL silica NPs, 121 or liposomes. 122 In addition, the use of particles composed of organometallic materials, 123 metal-dye composites, 124 or metal-polymer composites 125 have also been explored.…”

Design, Manufacturing and Functions of Pore-Structured Materials: From Biomimetics to Artificial

“…For example, as the active center, the mesoporous structure traps the reactive intermediates in its space, promotes coupling reactions, and achieves efficient catalytic performance [ 86 ]. Then, the high specific surface area and rich active sites of the mesoporous structure of the biomimetic probes are used to improve the indocyanine green loading capacity [ 87 ]. The mesopores of biomimetic probes improve biosafety, targeting efficiency and photoacoustic imaging stability because of its mesoporous properties of molecular recognition and space limitation.…”